Ondansetron’s QT prolongation is exhibited in a dose-dependent manner; hence, the FDA has advised to cease using the 32-mg single IV dosage. Objective: To review QT prolongation potential with newer nonselective serotonin reuptake inhibitor (non-SSRI) antidepressants. 03 Aug 2020 Interesting, the ambulatory surgery Guidelines suggest haldol, which at 0.5-2 mg IM or IV has been shown on meta-analysis to reduce PONV with a NNT of 4-6; however, it does cause QTc prolongation as well. None of these patients had adverse outcomes, such a dysrhythmia or death, at 1-week follow-up.This study shows that medications known to cause QTc prolongation are safe to use in therapeutic doses in patients with ESRD who have pre-existing QT prolongation. Metoclopramide 10 mg three times daily is effective in up to 40% of cases.There are conflicting data on the use of serotonin antagonists in refractory nausea and vomiting in palliative care. The patients were followed-up 1 week later.Twenty-nine percent (44/152) of the unfunded patients with ESRD presenting for HD at a county hospital had QT prolongation and were included with 107 total ED visits during the 4-week study period. Mikesell CE, Atkinson DE, Rachman BR. These include infections, cancer, pregnancy and the adverse effects of many drugs.Multiple neurohumoural pathways can induce nausea and vomiting. 2014;48:1620-1628. These include blockade of serotonin, histamine, adrenergic and muscarinic receptors.Metoclopramide (parenteral) – palliative care medicineMetoclopramide and paracetamol combinations – available as non-prescription medicinesOndansetron – chemotherapy or radiation- induced nausea and vomitingGranisetron – chemotherapy or radiation- induced nausea and vomitingPalonosetron – chemotherapy-induced nausea and vomitingTropisetron – chemotherapy-induced nausea and vomitingBlock neurokinin type 1 receptors in the central and peripheral nervous system.Cyclizine, doxylamine, promethazine and pheniramine all block muscarinic receptors.Block muscarinic receptors in vestibular nuclei, vomiting centre and higher brain centres.Hyoscine (parenteral) – palliative care medicine.Hyoscine (oral) – available as non-prescription medicine.Central inhibition of prostaglandin synthesis and encephalin release. A comparison of the risk of QT prolongation among SSRIs. 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