New Orleans, Louisiana BK virus (BKV) is a human polyomavirus that has been implicated as a common cause of late-onset hemorrhagic cystitis in patients who have undergone bone marrow transplantation [1, 2].BKV has also been shown to be a significant cause of tubulointerstitial nephritis, vasculopathy, and allograft dysfunction in kidney transplant recipients [].In contrast, reports of BKV … of BKV-infected transitional cells/no. This frequency was markedly higher than the rare infected cells previously reported among HIV-infected patients with asymptomatic BKV urinary shedding [Longitudinal analysis of BK virus (BKV)—infected transitional cells from a patient with prolonged and refractory hemorrhagic cystitis after 2 infusions of cidofovir. Hemorrhagic cystitis (HC) occurring after engraftment in recipients of allogeneic hematopoietic stem cell transplants (HSCT) has been associated with latent BK-virus (BKV) reactivation. To our knowledge this is the first systematic review for the management of BKV … Search for other works by this author on:
Several smaller normal transitional cells are also seen. Relationship of BK Polyoma Virus (BKV) in the Urine with Hemorrhagic Cystitis and Renal Function in Recipients of T CelleDepleted Peripheral Blood and Cord Blood Stem Cell Transplantations Yeon Joo Lee1, Junting Zheng2, Yovanna Kolitsopoulos1, Dick Chung1, Isabelle Amigues1, Tammy Son3, Kathleen Choo3, Jeff Hester4, Sergio A. Giralt3,5, Ilya G. … Major clinical manifestations of BKV infection include hemorrhagic cystitis, which is inflammation of the urinary bladder associated with bloody urine, in bone marrow transplant recipients; ureteral stenosis, or narrowing, and nephropathy in kidney transplant recipients. Several uninfected cells with pale nuclei are also seen. The administration of cyclophosphamide also likely contributed to the severity of his hemorrhagic cystitis, although cyclophosphamide-induced hemorrhagic cystitis is typically characterized by rapid onset and short duration of symptoms.Previous case reports have suggested a role for cidofovir in the treatment of BKV-associated hemorrhagic cystitis [The potential utility of cidofovir for the treatment of progressive multifocal leukoencephalopathy due to JC virus, a related human polyomavirus, has also been an area of active investigation. Multidose Priming and Delayed Boosting Improve PfSPZ Vaccine Efficacy against Heterologous
There are no high-quality comparative studies. An effective multi-disciplinary approach leading to early recognition and initiation of treatment is encouraged. Department of Pathology, Massachusetts General Hospital
There is insufficient evidence to recommend prophylactic quinolones. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplantsHuman polyoma virus-associated interstitial nephritis in the allograft kidneyTesting for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathyBK-related polyomavirus vasculopathy in a renal-transplant recipientTubulointerstitial nephritis due to a mutant polyomavirus BK virus strain, BKV(Cin), causing end-stage renal diseaseBK virus renal infection in a patient with the acquired immunodeficiency syndromeDisseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system diseaseBK virus as the cause of meningoencephalitis, retinitis, and nephritis in a patient with AIDSActivities of various compounds against murine and primate polyomavirusesTreatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovirCidofovir treatment of human polyomavirus-associated acute haemorrhagic cystitisStructure and function of the transcriptional control region of nonpassaged BK virusCytologic and biomolecular diagnosis of polyomavirus infection in urine specimens of HIV-positive patientsIncidence of BK virus and JC virus viruria in human immunodeficiency virus-infected and uninfected subjectsBK and JC viruses in human immunodeficiency virus type 1-infected persons: prevalence, excretion, viremia, and viral regulatory regionsAmplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reactionCidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leukoencephalopathyCidofovir in AIDS-associated progressive multifocal leukoencephalopathy: A monocenter observational study with clinical and JC virus load monitoringFailure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virusHighly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathyProlonged survival without neurological improvement in patients with AIDS-related progressive multifocal leukoencephalopathy on potent combined antiretroviral therapy© 2002 by the Infectious Diseases Society of America