Celecoxib pharmacokinetics was evaluated after single and multiple oral dosing; after dosing in a solution and as a solid; with and without food; and after administration into different sites of the GI tract using dog. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Clin Ther. Epub 2011 Apr 7.Watanabe Y, Namba A, Aida Y, Honda K, Tanaka H, Suzuki N, Matsumura H, Maeno M.Mediators Inflamm. 2015 Oct;110(10):1490-6. doi: 10.1038/ajg.2015.259. Pharmacokinetic parameters following an oral dose of 200 mg celecoxib administration were characterized, including Cmax, Tmax, Vd, kel, CL, AUC. 2000 Mar;38(3):225-42. doi: 10.2165/00003088-200038030-00003.Clin Pharmacokinet. If you do not receive an email within 10 minutes, your email address may not be registered, 2011 Jun;10(3):506-19. doi: 10.1111/j.1474-9726.2011.00688.x. Celecoxib, a nonsteroidal anti‐inflammatory drug, is frequently used to treat arthritis in humans with minimal gastrointestinal side effect compared to traditional NSAID s. The primary aim of this study was to determine the pharmacokinetic profile of celecoxib—a selective cyclooxygenase‐2 (COX ‐2) inhibitor in … After oral dosing, the drug reached a maximum concentration (mean ± Please check your email for instructions on resetting your password. Name must be less than 100 characters Celecoxib pharmacokinetics was evaluated after single and multiple oral dosing; after dosing in a solution and as a solid; with and without food; and after administration into different sites of the GI tract using dog. Celecoxib does not affect the pharmacokinetics of tolbutamide (CYP2C9 substrate), or glibenclamide to a clinically relevant extent. I have read and accept the Wiley Online Library Terms and Conditions of Use Celecoxib, a nonsteroidal anti‐inflammatory drug, is frequently used to treat arthritis in humans with minimal gastrointestinal side effect compared to traditional NSAIDs. 2009;2009:308596. doi: 10.1155/2009/308596. Celecoxib pharmacokinetics was evaluated after single and multiple oral dosing; after dosing in a solution and as a solid; with and without food; and after administration into different sites of the GI tract using dog. 2008 Mar;64(3):233-52. doi: 10.1007/s00228-007-0400-7. Celecoxib wird gut resorbiert und erreicht die maximalen Plasmakonzentrationen nach ca. In patients with rheumatoid arthritis celecoxib had no statistically significant effect on the pharmacokinetics (plasma or renal clearance) of methotrexate (in rheumatologic doses). Die Einnahme zu den Mahlzeiten (fettreiches Essen) verzögert die Resorption von Celecoxib um ungefähr 1 Stunde und erhöht die Bioverfügbarkeit um ungefähr 20%. Epub 2010 Feb 24.Eur J Clin Pharmacol. 1998 Oct;35(4):247-74. doi: 10.2165/00003088-199835040-00001.Pal A, Shenoy S, Gautam A, Munjal S, Niu J, Gopalakrishnan M, Gobburru J.Clin Drug Investig.