These regulations are in accordance with the requirements for good practices in the manufacture and Quality control of the Pharmaceutical Inspection Convention/Co-Operation Scheme (PIC/S) and the Directives of the European Commission. Soukoulis V, Boden WE, Smith SC et al. Nifedipine: dose-related increase in mortality in patients with coronary heart disease. Health outcomes associated with antihypertensive therapies used as first-line agents: a systematic review and meta-analysis. McLean AJ, Knight R, Harrison PM et al. Epstein ML, Seibel MA, Hill MR et al. Line Number: 84. 516. Treatment of hypertensive patients with diabetes. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. 527. 366. by Tee on Mon Apr 18, 2011 6:01 am. Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients: altered electrocardiographic and hypotensive responses. Drug interaction facts. How one randomized clinical trial ended fallacies from observational studies? Myers MG, Tobe SW. A Canadian perspective on the Eighth Joint National Committee (JNC 8) hypertension guidelines. 197. McEvoy GK, ed. Calcium-channel blocking agent; nondihydropyridine.IV management of supraventricular tachycardia (SVT), including rapid conversion to sinus rhythm of paroxysmal supraventricular tachycardias (PSVT) (e.g., those associated with Wolff-Parkinson-White or Lown-Ganong-Levine syndrome), and temporary control of rapid ventricular rate in atrial flutter or fibrillation.Vagal maneuvers and/or IV adenosine are considered first-line interventions for acute treatment of SVT when clinically indicated; if such measures are ineffective or not feasible, a nondihydropyridine calcium-channel blocker such as verapamil may be used.Also has been used for treatment of other SVTs (e.g., atrial tachycardiaAn oral treatment of choice to prevent recurrent PSVT.Management of chronic stable angina, Prinzmetal variant angina, and unstable angina.A drug of choice for the management of Prinzmetal variant angina (used alone or in combination with nitrates).β-Blockers are recommended as the anti-ischemic drugs of choice in most patients with chronic stable angina; calcium-channel blockers may be substituted or added in patients who do not tolerate or respond adequately to β-blockers.Experts recommend a nondihydropyridine calcium-channel blocker (e.g., diltiazem, verapamil) for the relief of ongoing or recurrent ischemia when β-blocker therapy is inadequate, not tolerated, or contraindicated in patients with unstable angina who do not have clinically important left ventricular dysfunction, increased risk of cardiogenic shock, or AV block.Oral management of hypertension, alone or in combination with other classes of antihypertensive agents.Calcium-channel blockers are recommended as one of several preferred agents for the initial management of hypertension according to current evidence-based hypertension guidelines; other preferred options include ACE inhibitors, angiotensin II receptor antagonists, and thiazide diuretics.Individualize choice of therapy; consider patient characteristics (e.g., age, ethnicity/race, comorbidities, cardiovascular risk) as well as drug-related factors (e.g., ease of administration, availability, adverse effects, cost).A 2017 ACC/AHA multidisciplinary hypertension guideline classifies BP in adults into 4 categories: normal, elevated, stage 1 hypertension, and stage 2 hypertension.Source: Whelton PK, Carey RM, Aronow WS et al. Bhat RP, Wasir HS. 1988 Joint National Committee. With respect to any legal dispute arising out of or in connection with the T&Cs or the services provided by the System, a legal action shall be brought to the competent courts of the Republic of Georgia, which shall hold the jurisdiction on the disputes. 379. St. Louis: JB Lippincott Co; 1990 (Jan):727.314. Acute use in SVT : Adenosine now first line though Verapamil may becoming bhack into favour. Our product range includes Health Care Products, Fast Aid Kit, Mistdress Spray Bandage, Vinodine Spray, Coolex Burn Relief Spray, Isopropanol Spray, Laspray - A trusted anaesthetic for a Dentist, Hands-On Hand Sanitizer, Personal Care Products, Deodorants, Shaving Foam, Self Defence Pepper Spray, Spraymint Mouth Freshner, Intimate Deo, Insect Killers : NP-P Range of Inscticides.