There was no evidence that higher doses confer any additional benefit.The recommended starting dose is 37.5 mg per day of Effexor XR for 7 days. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older.The pooled analyses of placebo-controlled studies in children and adolescents with MDD, Obsessive Compulsive Disorder (OCD), or other psychiatric disorders included a total of 24 short-term studies of 9 antidepressant drugs in over 4,400 patients. Withdrawal is the worst” This drug makes me feel like myself minus panicking. Run away. Should be called Sideffexor.” I also began to notice that I was feeling nauseous anytime I didn’t have a full stomach, so weight gain was inevitable. “DO NOT TAKE THIS DRUG I have had very bad anxiety for about 2 years now and I have been given venlafaxine one time to see if it helps. Provide supportive and symptomatic measures.Effexor XR is an extended-release capsule for once-a-day oral administration that contains venlafaxine hydrochloride, a serotonin and norepinephrine reuptake inhibitor (SNRI). Venlafaxine is well absorbed and extensively metabolized in the liver. Relapse during the double-blind phase was defined as follows: (1) a reappearance of major depressive disorder as defined by DSM-IV criteria and a CGI Severity of Illness item score of ≥4 (moderately ill), (2) 2 consecutive CGI Severity of Illness item scores of ≥4, or (3) a final CGI Severity of Illness item score of ≥4 for any patient who withdrew from the study for any reason. They are the worst headache if my life lasting hours, waking me from sleep, unable to speak, move, any eye movement increases the pain tenfold. Thank goodness I only took one dose if this. I experienced a severe brain fog, I couldn’t think properly, couldn’t respond. Effexor worked wonders! I used to be on Celexa but my anxiety was getting worse. These risk differences (drug-placebo difference in the number of cases of suicidality per 1,000 patients treated) are provided in Table 1.No suicides occurred in any of the pediatric studies. The reduction side effects have been horrible, made more manageable by using micronutrients but still losing a lot of school time. Some days, I feel the lows, but they are not as bad.” Consider dose reduction or discontinuation of treatment for patients who experience a sustained increase in blood pressure.Across all clinical studies with Effexor, 1.4% of patients in the Effexor XR treated groups experienced a ≥15 mm Hg increase in supine diastolic blood pressure (SDBP ) ≥ 105 mm Hg, compared to 0.9% of patients in the placebo groups. I didn't have any problems getting used to Effexor like others have. And zero panic attacks. There was insufficient information to determine the effect of age or race on outcome in these studies.The efficacy of Effexor XR as a treatment for Panic Disorder (PD) was established in two double-blind, 12-week, multicenter, placebo-controlled studies in adult outpatients meeting DSM-IV criteria for PD, with or without agoraphobia. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish venlafaxine from PCP and amphetamine.Venlafaxine did not cause malformations in offspring of rats or rabbits given doses up to 2.5 times (rat) or 4 times (rabbit) the maximum recommended human daily dose on a mg/mNeonates exposed to Effexor XR, other SNRIs, or SSRIs, late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. In these two studies, Effexor XR was statistically significantly more effective than placebo (for each fixed dose) on all three endpoints, but a dose-response relationship was not clearly established.Examination of subsets of the population studied did not reveal any differential responsiveness on the basis of gender.