The hair does not grow during this phase, and melanin production stops.This new research and new perspective on topical metformin may be helpful to compounders and patients in combination with some of the more well-known options. 1 FL OZ. Certainly we should look at balancing the hormones or metabolic disorders, but many times a quick solution is needed. She also provides optional sweeteners that Vets can incorporate into their recipes so that our furry friends can get the medicine they need in a flavor they will enjoy. Fabiana Banov provides a list of the NEW (and original) PCCA flavors available for veterinary use. The term “hirsutism” is of Latin origin, meaning excessive growth of stiff hair, or simply hairiness. 4.2 out of 5 stars 725. Improvement may be seen 4 to 8 weeks after treatment with this medicine. Crystal Aguh and her colleagues chose topical metformin to study given the enhanced safety of topical metformin over systemic metformin. They found that 10 % metformin compounded in lipderm cream would help reduce disease activity and improve hair in patients with CCCA. Conversely, hair follicles maintained in the absence of insulin or at typical levels prematurely entered a catagen-like state. If you’re taking metformin for hyperglycemia and aren’t getting enough vitamin B-12, your hair loss might be caused by either of those conditions and not directly by the metformin. A new study supports that use of topical 10 % metformin as a helpful treatment.Metformin is a well known diabetes drug. In this article, our three experts cover this all-too-important topic in the HRT conversation, on what current literature says about the usage of oral vs. topical estrogen discussion. In approximately 90% of hirsute women, the condition either is caused by an underlying polycystic ovarian syndrome or is idiopathic (of unknown cause).Regardless of the source, patients are always looking for options to help with unwanted hair, and even when the commercial product is available, it may not address everyone’s clinical need. He provides a brief history of transdermal pain therapy and evidence of the levels of efficacy PETPT has within medicine. Pharmacists and prescribers thinking outside the box and looking at literature through a different lens can create a new and innovative product to help with patients’ problems.Similar thinking is used for some commercial products. Compounded bioidentical hormone replacement therapy (BHRT) is an important treatment option for women around the world. Periorbital hyperpigmentation is caused by various external and internal factors, which makes it very complex to treat, but PCCA's Sara Hover, RPh, FAARM, discusses treatment options unique to personalized medicine that may help compounding pharmacies treat patients with this skin disorder. The cream is then further mixed, using our electronic mortar and pestle machine. This proportion was significantly (P < 0.05) greater than that in the Dianette group. Recent evidence has suggested that metformin may have more benefits than just diabetes. A few studies have examined the influence of metformin on hirsutism as the primary end point. Stay current on PCCA news and events, market trends, and all things compounding! In this second part of the article, they dive deeper into the BHRT conversation, discussing compounded topical estrogen as an option. Kelly and Gordon—in a 14 month, randomized, double-blind, placebo-controlled crossover trial—demonstrated a modest reduction in hirsutism at the end of treatment.4 Also, a six month, randomized, controlled trial of 70 patients with pol… Very recently, systemic usage of metformin for psoriasis and skin malignancies has shown promising results.Interestingly, though, topical metformin has also been used in hyperpigmentation disorders. I was interested to read an article about the use of topical metformin in the treatment of a scarring alopecia known as Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that affects women with afrotrextured hair. However, studies have shown that hair follicles that are exposed to excessive levels of insulin exhibit a higher growth rate. Approximately half of the metformin group recorded that their hair growth rate was reduced at T6. These statements are provided for educational purposes only. It should not be considered a substitute for professional medical advice. Here are some of the common options for these patients. Clearly they have a primary role in these diseases. With this information, I’ll look forward to expanding our study of metformin to CCCA.The second important point of this paper is that it reminds us that we have an array of non steroid options to consider in managing scarring alopecia. In the first part of this article, Pamela, Nat, and Sara shined a light on new health risk information compounders should consider when providing bioidentical hormone replacement therapy. Half of the metformin-treated patients responded with a reduced requirement for the use of cosmesis (T6 and T12). However, we must remember that our tool box is filled with other agents that hep reduce inflammation including topical calcineurin inhibitors (pimecrolimus, tacrolimus), metronidazole, Tofacitinib, Ruxolitinib and now … metformin too. That is, even though the topical mechanism of action for eflornithine is unknown, it is approved for topical use.Metformin is indicated as an off-label treatment for polycystic ovarian syndrome because it reduces circulating insulin, which decreases the concentration of free levels of androgens.