Myasthenia gravis prednisone taper lipitor

Any reoccurrence of symptoms within three months of follow-up screening will be also recorded.In most circumstances, for somebody to participate in a clinical trial, they need to live near the team of people who are conducting the research, because they need to be closely monitored.The study results will determine if prednisone can be reduced more rapidly in individuals with myasthenia gravis while still controlling their symptoms. Reducing prednisone treatment as quick as possible is therefore desired. Sometimes these details can be quite technical. In case of side effect, azathioprine will be replaced by mycophenolate mofetil.Rapid strategy consists of decreasing the prednisone dose if at each monthly consultation the patient fulfils the criteria for improvement or minimal manifestation state, in order to discontinue it before twelve months. Prednisone and azathioprine are both immunosuppressant drugs, commonly used to treat myasthenia gravis. For example, if prednisone treatment is abruptly stopped, the human body does not produce any cortisol. Prednisone and azathioprine are both immunosuppressant drugs, commonly used to treat myasthenia gravis. Pathology - Generalized myasthenia gravis (MG) is cause of muscle weakness that can have a significant impact on daily life activity but can also be, when respiratory or bulbar muscles are involved, life-threatening.Rationale - Additionally to thymectomy, which indication of is still debated in absence of thymoma, the long-term treatment of generalized myasthenia gravis includes usually prednisone and azathioprine. The starting dose is 0.75 mg/kg/day.Classical strategy consists of decreasing the prednisone dose if at each monthly consultation the patient fulfils the criteria for minimal manifestation state, in order to discontinue it before twelve months. Patients in both groups will also take azathioprine.In both groups, a senior neurologist who will not be aware of which treatment group the patients are in, will examine the participants each month and assess if their condition is improving or stabilising. SC039445 In some cases a life-long therapy may be essential. The starting dose is 1.5 mg/kg/2days. 6,7,9,23-25 Patients with myasthenia gravis are generally started on high doses of prednisone (60 to 100 mg/day) until the disease is in remission, then the dose is tapered to the lowest possible daily dose, and eventually switched to an every other day regimen. In the classical group, participants will receive a prednisone starting dose of 1.5 milligrams per kilogram of body weight every two days. The starting dose is 0.75 mg/kg/day.Classical strategy consists of decreasing the prednisone dose if at each monthly consultation the patient fulfils the criteria for minimal manifestation state, in order to discontinue it before twelve months. This leads to muscles that tire easily, especially when they are used repetitively. Recruiting This field is for validation purposes and should be left unchanged. In the rapid group individuals will start with half the dose of prednisone, but will receive the dose every day. Current treatments use a combination of drugs that suppress the immune system in order to allow normal transmission of signals to the muscle. 205395 Scottish Registered Charity No. This prevents the transmission of electrical pulses to the muscle telling it to contract. 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