Sublingual nitroglycerin is the most frequently used agent for the immediate treatment of angina. Administer oxygen and artificial ventilation, if necessary. Incidences of testicular tumors were 52% vs. 8% in controls. Similarly, it is not known which—if any—of these substances can usefully be removed from the body by hemodialysis.No specific antagonist to the vasodilator effects of nitroglycerin is known, and no intervention has been subject to controlled study as a therapy of nitroglycerin overdose. Syncope due to nitrate vasodilatation has been reported.Flushing, drug rash, and exfoliative dermatitis have been reported in patients receiving nitrate therapy.Nitroglycerin Sublingual Tablets are contraindicated in patients who are using a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE-5). Heart Medication: Nitroglycerin. If you have any questions about Nitroglycerin Sublingual Tablets, ask your doctor. They are supplied as:Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. If you give nitroglycerin, you dilate the vessels so less blood returns to the heart (increased venous capacitance->more blood distributed to venous system), decreased stroke volume of right heart. How does it work? Nevertheless, there was no evidence of mutagenicity in an In a 3-generation reproduction study, rats received dietary nitroglycerin at doses up to about 434 mg/kg/day for 6 months prior to mating of the F0 generation, with treatment continuing through successive F1 and F2 generations. These are not all the possible side effects of Nitroglycerin Sublingual Tablets. Betaloc: Metoprolol belongs to the class of medications called beta-blockers. The sublingual tablets also contain the inactive ingredients lactose monohydrate, glyceryl monostearate, pregelatinized corn starch, calcium stearate, and hydrophobic colloidal silica.Nitroglycerin, an organic nitrate, is a vasodilating agent. Mechanism of Action. Molecular weight: 227.09. Only the smallest dose required for effective relief of the acute angina attack should be used. As a result, any regimen of Nitro-BidThus, one appropriate dosing schedule for Nitro-BidEach tube of ointment and each box of foilpacs is supplied with a pad of ruled, impermeable, paper applicators. If methemoglobinemia is present, administration of methylene blue (1% solution), 1-2 mg per kilogram of body weight intravenously, may be required unless the patient is known to have G-6-PD deficiency. Recent studies of other formulations of nitroglycerin suggest that the maximal achievable daily duration of anti-anginal effect from nitroglycerin ointment will be about 12 hours.It is reasonable to believe that the rate and extent of nitroglycerin absorption from ointment may vary with the site and square measure of the skin over which a given dose of ointment is spread, but these relationships have not been adequately studied.In some controlled trials of other organic nitrate formulations, efficacy has declined with time. Symptoms of severe hypotension (nausea, vomiting, weakness, pallor, perspiration and collapse/syncope) may occur even with therapeutic doses.Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.Nitroglycerin produces dose-related headaches, especially at the start of nitroglycerin therapy, which may be severe and persist but usually subside with continued use.The following adverse reactions are discussed in more detail elsewhere in the label:Vertigo, dizziness, weakness, palpitation, and other manifestations of postural hypotension may develop occasionally, particularly in erect, immobile patients.