2 weeks ago 2009;67(4):445–54.Eap CB, Buclin T, Cucchia G, et al. After a single dose, apalutamide is predominantly metabolized by CYP2C8, and less by CYP3A4.Co-administration of apalutamide with CYP3A4, CYP2C19, CYP2C9, P-gp, BCRP or OATP1B1 substrates may cause loss of activity for these medications. Biochem Pharmacol. BMJ. Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping. Over 10 million scientific documents at your fingertips 1 Citations. Clin Pharmacol Ther. Eur J Clin Pharmacol. 1996;31(1):9–28.Andersson T, Miners JO, Veronese ME, Birkett DJ. 2001;69(3):114–21.Jaakkola T, Laitila J, Neuvonen PJ, Backman JT. 2006;61(1):70–8.Zhang W, Deng S, Chen XP, et al. • Pharmacokinetic interactions occur when the absorption, distribution, metabolism or elimination process of the object drug is altered by the precipitant drug and hence such … In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state.Systemic exposure (area under the plasma concentration–time curve) to single-dose apalutamide increased 68% with gemfibrozil but was relatively unchanged with itraconazole (study A). Alternatively interaction may be pharmacokinetic in which one drug, or dietary supplement, alters the absorption, distribution, metabolism or excretion of another drug. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Curr Drug Metab. You can also search for this author in 2017;79(5):1051–5.Jamani R, Lee EK, Berry SR, et al. As most drug administration in the daily clinical practice of anaesthesia is titrated toward a desired clinical effect, PK interactions are often not considered separately from PD … Scribd will begin operating the SlideShare business on September 24, 2020 Clin Pharmacol Ther. Cancer Res. Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. Activation status of the pregnane X receptor (PXR) influences vemurafenib availability in humanized mouse models. In short, interactions between drugs can be classified as pharmacokinetic and pharmacodynamic. You can also search for this author in If you continue browsing the site, you agree to the use of cookies on this website. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. 1997;54(11):1195–203.Heimark LD, Gibaldi M, Trager WF, O’Reilly RA, Goulart DA. Clin Ther. 2018;378(15):1408–18.Chi KN, Agarwal N, Bjartell A, et al. Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study. Comment goes here. 1 Altmetric. Peter Hellemans, Anna Mitselos, Peter Ward, James Jiao, and Caly Chien are current or former employees of Janssen Research & Development and hold/held stock in Johnson & Johnson.Protocols of both studies were reviewed by an independent ethics committee and institutional review board, and both studies were conducted in accordance with Good Clinical Practice and applicable regulatory requirements.Participants in both studies provided written informed consent.Please see the companion article titled “Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model.”Below is the link to the electronic supplementary material. Joan Carles reports advisory roles for Astellas, Bayer, Bristol-Myers Squibb, Johnson & Johnson, MSD Oncology, Pfizer, Roche, and Sanofi, and speakers’ bureau roles for Asofarma, Astellas, Bayer, and Johnson & Johnson outside the submitted work. 2019;381(1):13–24.De Vries R, Jacobs F, Mannens G, Snoeys J, Cuyckens F, Chien C, Ward P. Apalutamide absorption, metabolism, and excretion in healthy men, and enzyme reaction in human hepatocytes.