Author(s): Chuong Monica C, Taglieri Catherine A, Kerr Stephen G Issue: Nov/Dec 2017 - Volume 21, Number 6 View All Articles in Issue. Treat a duodenal or stomach (gastric) ulcer. Proton Pump Inhibitors & H-2 Blockers; Statins * Disclaimer: These statements have not been evaluated by the Food and Drug Administration. Kwok CS(1), Jeevanantham V, Dawn B, Loke YK. doi: 10.1002/14651858.CD010623.pub2. Free PMC article Conversely, PPIs may modify the acidic tumor microenvironment and inhibit vacuolar H Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication or Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease: Misleading Ranking Probabilities in Network Meta-analysis Gastroenterology. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Conflict-of-interest statement: None of the authors have potential conflicts (financial, professional, or personal) that are relevant to this publication. Proton pump inhibitors (PPIs) can reduce heartburn, acid reflux, and stomach ulcers. These products are not intended to diagnose, treat, cure or prevent any disease. COVID-19 is an emerging, rapidly evolving situation. Contrast effects of proton pump inhibitors in normal gastric mucosa and gastric cancer… Name must be less than 100 characters The However, doctors advise people not to use OCT PPIs for more than Most people can take PPIs without any problems. MNT is the registered trade mark of Healthline Media. 2015 Apr 21;21(15):4599-606. doi: 10.3748/wjg.v21.i15.4599.Curr Gastroenterol Rep. 1999 Dec;1(6):507-10. doi: 10.1007/s11894-999-0011-9.Parsons BN, Ijaz UZ, D'Amore R, Burkitt MD, Eccles R, Lenzi L, Duckworth CA, Moore AR, Tiszlavicz L, Varro A, Hall N, Pritchard DM.PLoS Pathog. Free PMC article Proton pump inhibitors are used to: Relieve symptoms of acid reflux, or gastroesophageal reflux disease (GERD). However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Author information: (1)Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, United Kingdom. Please enable it to take advantage of the complete set of features! Unable to load your delegates due to an error Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Contrast effects of proton pump inhibitors in normal gastric mucosa and gastric cancer cells. All rights reserved. Any stated results are not guaranteed and are not typical. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.© 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. As a result, doctors tend to recommend OTC, lower-dose versions of H2 antagonists for people who have occasional heartburn.The amount of time it takes for them to work and the length of time for which they are effective are two key differences between these medications.By comparison, PPIs can be effective for 24 hours, but they take longer to work.PPIs are some of the most widely prescribed medications in the U.S.