If you do not receive an email within 10 minutes, your email address may not be registered, Ryan L Crass, Pier Giorgio Cojutti, Manjunath P Pai, Federico Pea Antimicrobial Agents and Chemotherapy 2019, 63 (8) Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. Worryingly, in a recent retrospective analysis of 10 years of activity of linezolid TDM carried out at our centre we showed that 33.0% of 1049 patients receiving the fixed 600 mg every 12 h standard dose had a C min above this threshold. closed circle and solid line, observed unbound plasma linezolid concentration; dashed line, predicted unbound plasma linezolid concentration using the final model; closed square and long‐dashed line, observed platelet count; dotted line, predicted platelet count; PLT, platelet count; UNBOUND, unbound plasma linezolid concentration In the current study, we tried to identify patterns of platelet count associated with two fundamental types of mechanism for thrombocytopenia. Patients 1, 58 and 64 (A–C) are best described as showing inhibition of the synthesis of platelets. after dialysis; consider supplement if next maint. Target concentration intervention to optimize linezolid exposure is expected to reduce the risk of thrombocytopenia.All authors have completed the Unified Competing Interest form at Y.T. Tel./Fax: + 81 76 434 7584; E‐mail: Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New ZealandDepartment of Medical Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Medical Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New ZealandDepartment of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, JapanDepartment of Pharmacy, Sasebo Chuo Hospital, Nagasaki, JapanDepartment of Medical Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, JapanUse the link below to share a full-text version of this article with your friends and colleagues. If you do not receive an email within 10 minutes, your email address may not be registered, The serum and plasma samples were stored at −80°C until analysis. The following medications require renal dosage adjustments 3,4: Allopurinol (Zyloprim) Lithium (Lithobid) Acyclovir (Valtrex) Amantadine (Symmetrel) No dose adjustment is necessary when switching from intravenous to oral administration. Black dashed lines, 5th to 95th percentiles of the predicted linezolid concentrations; black solid line, median predicted linezolid concentration in 100 simulated subsets of total dataset; grey‐shaded areas, 95% confidence intervals of the prediction percentiles; red circles, observed linezolid concentration; red dashed lines, 5th and 95th percentiles of the observed linezolid concentrations; red solid line, median observed concentration; UNBOUND, unbound linezolid concentrationModel qualification using prediction‐corrected visual predictive checks (pc‐VPC) for platelet counts (mixture group 1 – inhibition of proliferation).