No significant differences between sublingual and oral administration were found for the elimination half‐life of triazolam (4.1 vs 3.7 hr) and the time of peak concentration (1.22 vs 1.25 hr) after dose. This depressant effect of selegiline, however, only attained 1/8 and 2/3, resp., of the sedative effect of the normal dose of the antihistamine chlorophenoxamine. Selegiline is a much stronger IMAO-B than hordenine, you need less from both substances: 5mg selegiline and 50mg of PEA can give you an amphetamine-like rush for 2 hours. the buildup of dopamine from the selegiline is what makes it synergized, you need there to be dopamine inhibition built-up. Also it kinda shields me from emotions. : XI'm getting Selegiline pretty soon. I'm not sure how it would affect me. Under the influence of chlorphenoxamine, performance becomes less regular and under fenetylline more regular.Selegiline does not differ significantly from the placebo. I think it will be a good middle of the road nootropic.a potent antidepressant and cognitive enhanced known for significantly raising dopamine levels in the brainWhat are you basing the cognitive enhancement claim on? From the early beginning to now, the SAW movies have been a staple in the horror franchise. Also, focus and memory does seem slightly enhanced.Increased tiredness and a distracting increase in sex drive were the ultimate deal killers for me.Indeed. The effects have been extremely positive so far but unfortunately the insomnia is real. EDIT2: This being said, I still maintain that the metabolites are not harmful and contribute toward selegiline's nootropic effects. Oral selegilene is about 10% bioavailable. I'm extremely interested to hear from anyone in this sub who's tried it...Thanks. They are not neurotoxic and possess 1/200th the dopamine releasing ability of their dextrorotatory counterparts. Not anyone will like this effects. Like sublingual, it also avoids first pass metabolism and the bioavailability likely surpasses it. For a better experience, please enable JavaScript in your browser before proceeding. Yes, oral selegiline (at least selgin) dissolves if you put it under your tongue. JavaScript is disabled. The results were compared with the effects of the psychostimulant fenetylline and the depressant-antihistamine chlorphenoxamine, and with a placebo.While fenetylline and chlorphenoxamine produced the anticipated effects with regard to an improvement or deterioration in performance in all parameters, selegiline resulted in a slightly longer motor reaction time and an increase in control errors, and in a significantly longer mental processing time.In comparison with the placebo, selegiline increased the motor reaction time by 0.8 +/- 1.95% and mental processing time by 4.1 +/- 1.7%. - posted in Supplements: I've been taking Selegiline for over six months and it's working very well (blocking negative thinking, mostly) But there's something that really concerns me in the long run. Seeing selegiline metabolizes primarily into l-amphetamine and l-methamp, would it be wise to avoid taking your regular dose when you plan to take stimulants? and nuke". the buildup of dopamine from the selegiline is what makes it synergized, you need there to be dopamine inhibition built-up. You mean the methamphetamine ones that can cause a false positive on a drug test. Yes, oral selegiline (at least selgin) dissolves if you put it under your tongue. It kills MAO which takes 15 to replenish. The lowest dose is 6mg/24hr and the highest is 12mg/24hr. Like sublingual, it also avoids first pass metabolism and the bioavailability likely surpasses it. Selegilene's sublingual bioavailability might be significantly higher than the oral route. It has also been proven to Selegiline can be an MAO-A inhibitor at high enough doses.I'm pretty stingy with what I spend money on when it comes to nootropics, but the anecdotal reports I've seen around the Internet have convinced me to fork over $100 for a 300mg bottle of the stuff. gotta get it regulated in your system first, then you can intake uppers. Based on others usage reports, I tried 250mg PEA 30 minutes after 1 mg selegiline. Awesome. Have been doing it this way ever since I started taking selegiline because I also read that is the best way to take it and I was also worried about the metabolites.Can't say how effective it is vs. just swallowing the tablets because I haven't compared...I haven't read of any formulations, I'm sure there are some though if you want to mix with water and use a dropper, too much work for me though.I also read that is the best way to take it and I was also worried about the metabolitesWhat you read is incorrect, there is nothing to indicate that by bypassing first pass metabolism, you avoid the metabolites.