Given the widespread usage of statins, diagnosticians should be aware of cutaneous reactions associated with this class of medications. The patient was tapered off methotrexate and there was no recurrence of his lesions.Statins, an example of the most commonly prescribed medications in adults, lower lipid levels through inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme-A reductase. I stopped when I developed an itchy skin rash and it cleared up straight away. Copyright © 2020 Leaf Group Ltd., all rights reserved. These symptoms may be worse when you start the medication but tend to improve as your body gets used to the medicine. P-gp is located at luminal apical cells and acts on both endogenous organic compounds and many common medications, including pravastatin [Case reports suggest that drug-drug interactions and genetic predispositions may precipitate adverse reactions for patients taking pravastatin; statins are very well tolerated overall. Dermatologic events are often overlooked as arising from medications, particularly those which are taken chronically. His daily medications included the following: allopurinol 300 mg, hydrochlorothiazide 25 mg, aspirin 81 mg, pravastatin 20 mg, and colchicine 0.6 mg. In any elderly patient with a new rash, it is worth remembering that both recently introduced and longstanding medications may play a role in skin changes and that the resolution of these changes may take weeks to months once the offending agent has been discontinued. I've been on seroquel for insomnia ever since I was 18. In this report, we describe a case of a statin-induced eczematous dermatitis with a psoriasis-like clinical presentation and review the skin manifestations that may arise from statin thera… I have begun to itch so bad, in late October, that a red rash develops wherever I have scratched - it doesn't go away. Background. Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. This is an open access article distributed under the We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Permeability glycoprotein (P-gp) is an ATP-binding cassette transporter found in the small intestine, liver, kidneys, and blood-brain barrier. Respiratory System . Finally, the patient underwent a trial off his pravastatin to rule out the statin as an etiologic agent. Moreover, elderly patients are prone to pharmacologic interactions due to multiple medications. Statins have become the cornerstone of hypercholesterolemia pharmacotherapy in the elderly [An 82-year-old man with a history of gout, hypercholesterolemia, and multiple nonmelanoma skin cancers was referred to our dermatology clinic for evaluation of pruritic lesions affecting the skin of the bilateral posterior arms for several weeks. Select one or more newsletters to continue. With respect to specific medications, atorvastatin has been reported to cause photosensitivity, edema, cheilitis, urticaria, and skin ulceration; lovastatin has caused pruritus and/or rash in up to 5% of patients; and simvastatin has been associated with lupus-like syndrome, lichenoid drug eruptions, cheilitis, photosensitivity, and vesiculobullous eruptions [The mechanism of statin-induced cutaneous eruptions is not well understood. From searching the literature, three cases identified pravastatin as the cause of an adverse reaction [This case demonstrates that pravastatin may be associated with psoriasis-like eczematous lesions that are resistant to treatment with steroids and immunosuppressive therapy. On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age. The most commonly reported adverse dermatological reaction is a widespread, eczematous rash or hypersensitivity reaction.