This can be increased to levels as indicated above.The change from other medications to acetazolamide should be gradual and in accordance with usual practice in epilepsy therapy.For diuresis in congestive heart failure, the starting dose is usually 250 to 375 mg once daily in the morning (5 mg/kg). Select one or more newsletters to continue. Acetazolamide Tablets are also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness in climbers attempting rapid ascent and in those who are very susceptible to acute mountain sickness despite gradual ascent.Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.Supportive measures are required to restore electrolyte and pH balance. Adults: For diuresis, the starting dose is usually 250 - 375mg (1-1½ tablets) once daily in the morning. The best results to date have been seen in petit mal in children. Precaution is advised for early detection of such reactions and the drug should be discontinued and appropriate therapy instituted.In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, acetazolamide, which may precipitate or aggravate acidosis, should be used with caution.Gradual ascent is desirable to try to avoid acute mountain sickness. Under certain circumstances, however, very large doses have been given in conjunction with other diuretics in order to secure diuresis in complete refractory failure.Adverse reactions common to all sulfonamide derivatives may occur: anaphylaxis, fever, rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), crystalluria, renal calculus, bone marrow depression, thrombocytopenic purpura, hemolytic anemia, leukopenia, pancytopenia and agranulocytosis. This may be particularly important in the management of acetazolamide overdosage when complicated by the presence of renal failure.Acetazolamide should be used as an adjunct to the usual therapy. If significant changes occur, early discontinuance and institution of appropriate therapy are important. Mfd. Updated In the eye, this inhibitory action of acetazolamide decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in cases of glaucoma and even in certain nonglaucomatous conditions. The diuretic effect of acetazolamide is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. Pulmonary function (e.g., minute ventilation, expired vital capacity and peak flow) is greater in the acetazolamide treated group, both in subjects with AMS and asymptomatic subjects. Do not use acetazolamide in larger or smaller amounts or for longer than recommended.Your dose of this medicine will depend on the condition you are treating. Khi acetazolamid dùng đồng thời với các thuốc chống động kinh khác, liều ban đầu 250 mg/ngày, sau đó tăng dần. If you take acetazolamide for congestive heart failure, your doctor may tell you to skip your medication for a day. Copy the URL below and paste it into your RSS Reader application. Uống 4 - 30 mg (thường lúc đầu 10 mg)/kg/ngày chia liều nhỏ có thể tới 4 lần/ngày, thông thường 375 mg đến 1000 mg/ngày. Keep the bottle tightly closed when not in use.Take the missed dose as soon as you remember. Sensitizations may recur when a sulfonamide is readministered irrespective of the route of administration.