2003, 88: 204-210. Box 2040, 3000, Rotterdam, CA, The NetherlandsYou can also search for this author in The clinical picture consists of gynecomastia, accelerated growth and premature bone maturation due to excessive peripheral estrogen synthesis. 10.1210/jcem-51-5-1128.Strain GW, Zumoff B, Miller LK, Rosner W, Levit C, Kalin M, Hershcopf RJ, Rosenfeld RS: Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men. 10.1111/j.1365-2265.1995.tb01890.x.Harada N, Sasano H, Murakami H, Ohkuma T, Nagura H, Takagi Y: Localized expression of aromatase in human vascular tissues. J Bone Miner Res. 1995, 80: 3689-3698. 10.1200/JCO.2005.07.097.de Ronde W: Therapeutic uses of aromatase inhibitors in men. 1999, 70: 237-241. 10.1016/j.fertnstert.2010.09.021.Clark RV, Sherins RJ: Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Aromatase inhibitors are widely prescribed for hormone-responsive breast carcinoma in postmenopausal women. Cancer Res. 1988, 66: 1019-1023. 10.1210/jc.84.6.1966.Kley HK, Deselaers T, Peerenboom H, Kruskemper HL: Enhanced conversion of androstenedione to estrogens in obese males. J Clin Endocrinol Metab. J Clin Invest. 10.1210/jc.86.1.192.Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL: Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. 1980, 51: 1128-1132. Med Hypotheses. J Urol. 2003, 88: 3785-3793. 2001, 165: 837-841. 10.1038/sj.pcan.4500782.Hayes TG: Pharmacologic treatment of male breast cancer. 10.1016/S0960-0760(99)00114-4.Schindler AE, Ebert A, Friedrich E: Conversion of androstenedione to estrone by human tissue. Endocrinology. 10.1210/jc.76.1.151.Kreher NC, Pescovitz OH, Delameter P, Tiulpakov A, Hochberg Z: Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole. 2008, 158: 741-747. 10.1517/14656560903200634.Soon Wong N, Seong Ooi W, Pritchard KI: Role of gonadotropin-releasing hormone analog in the management of male metastatic breast cancer is uncertain. 10.1212/01.WNL.0000149639.25136.CA.Department of Internal Medicine, Kennemer Gasthuis, P.O. 10.1056/NEJMoa021559.Thürlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Rabaglio M, Smith I, Wardley A, Price KN, Goldhirsch A: A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. 10.1016/j.bone.2008.05.011.Deladoëy J, Flück C, Bex M, Yoshimura N, Harada N, Mullis PE: Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy. 2009, 94: 4785-4792. Aromatase inhibitors may be used to treat or prevent gynecomastia. J Clin Endocrinol Metab. 10.1172/JCI10942.Geisler J, Haynes B, Anker G, Dowsett M, Lønning PE: Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. Health care providers and patients are recognizing the role diet may play in treating certain conditions. Hum Genet. 10.1210/jc.83.4.1348.Shozu M, Sebastian S, Takayama K, Hsu WT, Schultz RA, Neely K, Bryant M, Bulun SE: Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. 2005, 90: 6396-6402. The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes [To date, eight males with aromatase deficiency have been described: seven adults [On the other hand, several, mostly familial cases of aromatase excess have been reported. Aromatase inhibitors in men: effects and therapeutic options. Hyperaromatization. 2006, 64: 510-513. 10.1542/peds.2010-0596.Hero M, Norjavaara E, Dunkel L: Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial.