3. Consensus development conference on antipsychotic drugs and obesity and diabetes. Asenapine: efficacy and safety of 5 and 10mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder. Fuller MA, Shermock KM, Secic M et al. 53. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a … Food and Drug Administration. From the FDA website. 2013 Nov-Dec;36(6):223-38. doi: 10.1097/WNF.0b013e3182aa38c4.Alvarez-Herrera S, Escamilla R, Medina-Contreras O, Saracco R, Flores Y, Hurtado-Alvarado G, Maldonado-García JL, Becerril-Villanueva E, Pérez-Sánchez G, Pavón L.Front Endocrinol (Lausanne). Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Young RC, Biggs JT, Ziegler VE et al. Food and Drug Administration. Safety and Efficacy from an 8 Week Double-Blind Trial and a 26 Week Open-Label Extension of Asenapine in Adolescents with Schizophrenia. Lieberman JA. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm053171.htm74. 1 Effects of the drug on nursing infants and on milk production also not known. A fall risk assessment should be completed recurrently in at-risk patients on long-term antipsychotic therapy. Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation. Citrome LL. 58. McIntyre R, Aplhs L, Cohen et al. McIntyre RS, Cohen M, Zhao J et al. Princeton, NJ: Bristol-Myers Squibb Company; 2004 Mar 25. 51. In: Abstracts of the 1st International Conference on Therapeutic Risk Management and 19th International Conference on Pharmacoepidemiology, Philadelphia, PA, 2003 Aug 21-24. East Hanover, NJ: Personal communication.63. Sexson WR, Barak Y. 57. Asenapine versus olanzapine in acute mania: a double-blind extension study. 52. 32. American Psychiatric Association. 65. Titusville, NJ: Personal communication.64. Olanzapine/risperidone and diabetes risk. Contents: Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Adverse Reactions Drug Interactions Use in Specific Populations http://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM166433.pdf24. A report for the Minister of State for Care Services. US Food and Drug Administration. Asenapine exhibits high affinity for serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors, dopamine D2, D3, D4, and D1 receptors, α1 and α2-adrenergic receptors, and histamine H1 receptors, and moderate affinity for H2 receptors. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2004 Apr 1. Bishara D, Taylor D. Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. Lahti AC, Tamminga CA. Geller WK, MacFadden W. Diabetes and atypical neuroleptics. New York NY: Pfizer Global Pharmaceuticals; 2004 Aug. From the FDA website. 94. 86. Citrome L, Jaffe A, Levine J et al. Gianfrancesco F, Grogg A, Mahmoud R et al. 9. Sumiyoshi T, Roy A, Anil AE et al. Nursing Central is an award-winning, complete mobile solution for nurses and students. 25. Isaac MT, Isaac MB. 44. 91. The increase in risk of diabetes mellitus from exposure to second generation antipsychotic agents. This article reviews the pharmacological profile and published efficacy and tolerability/safety data of iloperidone, asenapine and lurasidone, the most recent atypical antipsychotics to be approved in the USA for the treatment of schizophrenia. Arlington, VA; 2009 Sep. From the American Psychiatric Association web site. Select one or more newsletters to continue. Differential effects of risperidone, olanzapine, clozapine, and conventional antipsychotics on type 2 diabetes: findings from a large health plan database. Press release.13. 80. 84. For each drug, comparative and real-world effectiveness studies are lacking, as are effectiveness and safety data in elderly, young and pregnant/nursing patients. 35. Novartis Pharmaceuticals Corporation. Rockville, MD; 2008 Jun 16.