Treating schizophrenia with a patch instead of a pill may make it easier for people to follow their medication plan. A New Drug Application (NDA) has been submitted to the Food and Drug Administration (FDA) for a transdermal patch formulation of asenapine for the treatment of schizophrenia. The patch is a formulation of the atypical antipsychotic asenapine. The LTS asenapine TTS has successfully completed a Phase I clinical study and further patent applications covering the development have been filed. Advise patient to notify health care professional if these occur,mayrequirediscontinuation. Low-dose and high-dose HP-3070 patches were designed to be equivalent in terms of overall medication exposures to sublingual asenapine 5 and 10 mg twice daily, respectively. All rights reserved. Unlike an injectable that can last 2 to 4 weeks, people can still decide on a daily basis to end their treatment, Brendel says.Asenapine has a similar risk versus benefit profile as the other atypical antipsychotics that are available, he notes. HP-3070 is an investigational asenapine-containing Transdermal Drug Delivery System (TDDS), developed by Hisamitsu Pharmaceutical, to be applied to the skin for the treatment of schizophrenia. But it’s unlikely it can substantially improve treatment adherence overall. The asenapine TTS is a twice-weekly transdermal patch for the treatment of schizophrenia and is one of LTS’ proprietary projects. Ex: Fluvoxamine, ciprofloxacin. It can also make asenapine available to those who have gastrointestinal issues when they take it in pill form.Stevens also likes that the patch can be put somewhere on the body, so a parent or doctor can check that it’s being used. The patch could lead to fewer side effects since it bypasses the gut, which could be helpful for some people who experience gastrointestinal symptoms when on the medication. It involved testing the medication on 616 people with schizophrenia.Schizophrenia is a mental disorder that can disrupt thoughts and emotional responses, affect perceptions, and impact social interactions. The transdermal patch is a formulation of the atypical antipsychotic The patch is applied once daily to provide equal concentrations of the medication over a 24-hour span.“As people living with schizophrenia cycle through treatments, their therapeutic options narrow, leaving them and their caregivers looking for new treatment options,” Dr. Leslie Citrome, a clinical professor of psychiatry and behavioral sciences at New York Medical College in Valhalla, New York, said in a “In addition to offering a new delivery option, transdermal patches can also provide caretakers and healthcare providers with a nonintrusive, visual confirmation that a treatment is being utilized,” Citrome said.The transdermal application of the medication was demonstrated in an international double-blind, placebo-controlled study. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for ASENAPINE. Our website services, content, and products are for informational purposes only. It presents with psychotic symptoms, such as hallucinations, delusions, unusual thoughts, as well as other symptoms. Inform patient that oral ulcers, blisters, peeling/sloughing,and inflammation may occur at application site. Healthline Media does not provide medical advice, diagnosis, or treatment. Asenapine is a second generation atypical antipsychotic currently available as a sublingual formulation for the treatment of schizophrenia in adults. No dosage adjustment for mild to moderate hepatic impairment (Child-Pugh A and B)Risk of Leukopenia, Neutropenia, and Agranulocytosis.Monitor for hyperglycemia/diabetes mellitus, dyslipidemia, and weight gain.SECUADO may enhance the effects of certain antihypertensive agents.Asenapine may enhance the inhibitory effects of paroxetine on its own metabolism by CYP2D6= increases paroxetine concentration.SECUADO® (asenapine) transdermal system package insert. 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