Although he is still quite weak, he often doesn't even bother to use his cane now. Consult your doctor before breast-feeding.Drug interactions may change how your medications work or increase your risk for serious side effects. This eMedTV resource contains other Sinemet CR warnings and precautions, including information on what to tell your doctor before using this medication. Selecting these links This medication may take a little longer to work in the morning than the immediate-release medication because it is absorbed more slowly. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:This is not a complete list of possible side effects. Do not store in the bathroom. I used to take Sinemet CR 50/250 overnight (as well as various daytime medications. This effect is harmless, but your clothes may be stained.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Iron can reduce the amount of this medication absorbed by the body. Symptoms of overdose may include: severe dizziness, irregular heartbeat, mental/mood changes (such as agitation).Laboratory and/or medical tests (such as heart/kidney/liver function, complete blood count) should be performed periodically to monitor your progress or check for side effects. You should not take Sinemet CR if you have narrow-angle glaucoma or use certain medications. Kaiser Permanente health plans around the country: Kaiser Foundation Health Plan, Inc., in Northern and Southern California and Hawaii • Kaiser Foundation Health Plan of Colorado • Kaiser Foundation Health Plan of Georgia, Inc., Nine Piedmont Center, 3495 Piedmont Road NE, Atlanta, GA 30305, 404-364-7000 • Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc., in Maryland, Virginia, and Washington, D.C., 2101 E. Jefferson St., Rockville, MD 20852 • Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St., Suite 100, Portland, OR 97232 • Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc., 601 Union St., Suite 3100, Seattle, WA 98101 Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Carbidopa-levodopa CR (Sinemet ® CR) is a prescription medication most frequently used to treat Parkinson's disease. Search Results for levodopa and carbidopa (DUOPA, PARCOPA, RYTARY, SINEMET, SINEMET CR) Worst Pills, Best Pills is a project of Public Citizen's Health Research Group. Take your next dose at the regular time. If it is near the time of the next dose, skip the missed dose. As you can see, this schedule can be hard to maintain. If you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities until you have discussed this effect with your doctor. An "on-off" effect might also occur, in which sudden short periods of stiffness occur. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Consult your doctor for more details.People with Parkinson's disease may have an increased risk for developing skin cancer (melanoma). If any of these effects persist or worsen, tell your doctor or pharmacist promptly.This medication may cause saliva, urine, or sweat to turn a dark color. Sinemet CR contains 50 mg of the active ingredient carbidopa and 200 mg of the active ingredient levodopa per tablet. Consult your doctor or pharmacist for more details.The dosage is based on your medical condition and response to treatment. Tell your doctor promptly if you have a mole that gets bigger or looks different, or if you have other unusual skin changes. Make sure laboratory personnel and all your doctors know you use this drug.If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. (See also Side Effects section. This sleep effect may occur anytime during treatment with this medication even if you have used this medication for a long time.