For more information, see the CKS topic on Diabetes - type 2. Calcium channel blockers are available in short-acting and long-acting forms. The bars indicate the 95 percent confidence intervals. Once-daily formulations of diltiazem are recommended — there is little difference in cost compared with twice-daily formulations, and once-daily dosage regimens might be more convenient for some people. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services.Other investigators participating in the Systolic Hypertension in Europe trial are listed in the Appendix.Recent reports suggest that calcium-channel blockers may be harmful in patients with diabetes and hypertension. If you do not receive an email within 10 minutes, your email address may not be registered, Thus, our findings do not support the hypothesis that the use of long-acting calcium-channel blockers may be harmful in diabetic patients.Supported by Bayer (Wuppertal, Germany) and the National Fund for Scientific Research (Brussels, Belgium). However, antihypertensive treatment was similar in the diabetic and nondiabetic patients (The blood pressure decreased to the same extent in the diabetic and nondiabetic patients. The results of the study showed that those who used calcium channel blockers had 5 mg/dL lower serum glucose than those who didn’t use. ); the London School of Hygiene and Tropical Medicine, London (A.E.F. And animal research suggests they help control emotional behavior.Overall, the investigators found, patients were less likely to be admitted to a psychiatric hospital during periods where they had prescriptions for any of those medications, versus other times.They were also less likely to self-harm, which includes suicide attempts. In the diabetic patients, the mean (±SD) systolic blood pressure at randomization was 175.3±10.5 mm Hg, and the mean diastolic pressure was 84.5±6.3 mm Hg; in the nondiabetic patients, the mean pressures were 173.7±9.9 and 85.6±5.8 mm Hg, respectively. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Calcium channel blockers are now widely used and there have been case reports of hyperglycemia with nifedipine. Compared to CCB non-users, verapamil users had on average 10 mg/dL lower serum glucose, with considerably greater differences seen among insulin users: 24 and 37 mg/dL lower serum glucose among users of insulin and oral agents and users of insulin alone, respectively. Once-daily formulations of verapamil are recommended. Cardiovascular disease is the leading cause of morbidity and mortality among patients with diabetes mellitus.The Systolic Hypertension in Europe (Syst-Eur) Trial recently reported that antihypertensive therapy initiated with the dihydropyridine nitrendipine reduced the risk of fatal and nonfatal stroke, as well as all cardiovascular events combined, in older patients with isolated systolic hypertension.The protocol of the Syst-Eur trial, described in detail elsewhere,After stratification according to center, sex, and previous cardiovascular complications,An end-point committee, whose members were unaware of the treatment assigned, validated all end points by reviewing the patients' medical records and other documents, requesting detailed written information from the investigators, or both. Medicine, London ( A.E.F, University of Leuven, Belgium ( L.T., R.F in fully adjusted generalized models. 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