Consider DPP-4 inhibitors as a possible cause for severe joint pain and discontinue drug if appropriate.Postmarketing cases of bullous pemphigoid requiring hospitalization have been reported with DPP-4 inhibitor use. advice about side effects. Overall discontinuation of therapy due to adverse reactions was 6.8% with Alogliptin tablets 25 mg compared to 8.4% with placebo or 6.2% with active comparator.Adverse reactions reported in ≥4% of patients treated with Alogliptin tablets 25 mg and more frequently than in patients who received placebo are summarized in Hypoglycemic events were documented based upon a blood glucose value and/or clinical signs and symptoms of hypoglycemia.In the monotherapy study, the incidence of hypoglycemia was 1.5% in patients treated with Alogliptin tablets compared to 1.6% with placebo. These reactions include anaphylaxis, angioedema and severe cutaneous adverse reactions, including Stevens-Johnson syndrome. Cutting the 100mg pills in half could indeed cut your medication bill, but there’s a right way and a wrong way to split pills.” You can ask your pharmacist to cut pills in half for you. Two minor metabolites were detected following administration of an oral dose of [14 C] alogliptin, N-demethylated, M-I (less than 1% of the parent compound), and N-acetylated alogliptin, M-II (less than 6% of the parent compound). Sleepiness associated with your condition can add to this. I guess we all react differently to different medications. In a fertility study in rats, alogliptin had no adverse effects on early embryonic development, mating or fertility at doses up to 500 mg/kg, or approximately 172 times the clinical dose based on … The curves for placebo and Alogliptin tablets overlap throughout the duration of the study. In this clinical context, if the patient is found to have clinically significant liver enzyme elevations and if abnormal liver tests persist or worsen, Alogliptin tablets should be interrupted and investigation done to establish the probable cause. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (Keep this medication in the container it came in, tightly closed, and out of reach of children. Alogliptin tablets may be administered without regard to the timing of the dialysis. Estimated glomerular filtration rate decreased by 25% or more in 21.1% of patients treated with Alogliptin tablets and 18.7% of patients treated with placebo. Patients were maintained on their insulin regimen (median dose = 55 IU) upon randomization and those previously treated with insulin in combination with metformin (median dose = 1700 mg) prior to randomization continued on the combination regimen during the treatment period. Your doctor may also tell you how to check your response to alogliptin by measuring your blood or urine sugar levels at home. In glycemic control trials in patients with type 2 diabetes, acute pancreatitis was reported in 6 (0.2%) patients treated with Alogliptin tablets 25 mg and 2 (<0.1%) patients treated with active comparators or placebo. Administration of Alogliptin tablets with a high-fat meal results in no significant change in total and peak exposure to Alogliptin. Call your doctor or get medical Lactic acidosis is a medical emergency and must be treated in a hospital. Cytochrome (CYP) P450-related metabolism is negligible. Coadministration of Alogliptin tablets and pioglitazone provided statistically significant improvements in A1C and FPG compared to placebo, to Alogliptin tablets alone or to pioglitazone alone when added to background metformin therapy Improvements in A1C were not affected by gender, age or baseline BMI.The mean increase in body weight was similar between pioglitazone alone and Alogliptin tablets when coadministered with pioglitazone.In a 26 week, placebo-controlled study, a total of 493 patients inadequately controlled on a thiazolidinedione alone or in combination with metformin or a sulfonylurea (10 mg) (mean baseline A1C = 8%) were randomized to receive Alogliptin tablets 12.5 mg, Alogliptin tablets 25 mg or placebo.