Medications That Make You Tired. contact dermatitis).Only recommended for use on cold sores on the lips and face.Aciclovir cream contains a specially formulated base and should not be diluted or used as a base for the incorporation of other medicaments.Probenecid increases the mean half-life and area under the plasma concentration curve of the systemically administered aciclovir. Doses of 800mg five times daily (4 g per day), have been administered without adverse effects. Two generation studies in mice did not reveal any effect of orally administered aciclovir on fertility.There is no experience of the effect of aciclovir tablets on human female fertility. Each gram of ZOVIRAX Cream 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum.Acyclovir is a white, crystalline powder with the molecular formula C The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6 The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. The in vitro studies used human skin biopsates, whilst the bioassays either used human skin grafts on mice or were carried out in the human eye (3 patients). in the oral cavity, the eye or the vagina), as local irritation may occur. ZOVIRAX Cream 5% is a formulation for topical administration. It allows continued monitoring of the benefit/risk balance of the medicinal product. in the oral cavity, the eye or the vagina), as local irritation may occur. If you have any concerns about ZOVIRAX Cream, ask your doctor. Other drugs affecting renal physiology could potentially influence the pharmacokinetics of aciclovir. This summary is not meant to take the place of your doctor's advice.ZOVIRAX Cream is a prescription medicine that is applied to the skin to treat cold sores (herpes labialis) that occur on the face or lips. The cream must not be applied to the mucous membranes (e.g. Both ZOVIRAX Cream and vehicle showed a high and cumulative irritation potential. for 5 days. ZOVIRAX Cream is supplied as follows:Read this information before you start using ZOVIRAX (acyclovir) Cream and each time you refill your prescription. You will need to talk about the benefits and risks to you and the baby. Acyclovir Cream is not a cure for cold sores. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.3 mg/kg/day. Aciclovir tablets have been shown to have no definite effect upon sperm count, morphology or motility in man.Following oral administration of 200 mg aciclovir five times a day, aciclovir has been detected in breast milk at concentrations ranging from 0.6 to 4.1 times the corresponding plasma levels. The excipient cetyl alcohol can cause local skin reactions(e.g. Nursing mothers who have active herpetic lesions near or on the breast should avoid nursing.In 5 double-blind, placebo-controlled trials, 1,124 patients were treated with ZOVIRAX Cream and 1,161 with placebo (vehicle) cream. Read all information given to you. Keep ZOVIRAX Cream out of the reach of children.Do not use ZOVIRAX Cream for a condition for which it was not prescribed. Single intravenous doses of up to 80mg/kg have been inadvertently administered without adverse effects. Of 202 evaluable subjects, possible cutaneous sensitization reactions were observed in the same 4 (2%) subjects with both ZOVIRAX Cream and vehicle, and these reactions to both ZOVIRAX Cream and vehicle were confirmed in 3 subjects upon rechallenge. The treated area corresponded to 10% of the body surface. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. There are no reports concerning an overdose of aciclovir cream.No untoward effects would be expected if the entire contents of a 20g tube of the cream were ingested. Clinical isolates with reduced sensitivity showed a relative lack of virus thymidine kinase treatment with aciclovir be taken avoid... Acyclovir up to 0.3 mg/kg/day clinical studies: kidney disease ; or the cap on the tube is closed... Acyclovir into acyclovir monophosphate, a synthetic nucleoside analogue active against herpes viruses Cream to people. 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