In fact, it is considered to be very effective in inducing ovulation and is effective in 65 to 75% of cases, a success rate that is identical to that of clomiphene. Speak to a health care provider for information particular to your case. During pregnancy, tamoxifen and its metabolites interact with rapidly growing and developing embryonic and fetal tissues. Desmarais JE, et al. Breast cancer patients who take the drug tamoxifen for five or more years may be at increased risk of developing a rare but aggressive breast cancer in their opposite breast, but tamoxifen … Tamoxifen is also used as a female infertility treatment drug, generally on a short-term basis. It is definitely possible to get pregnant while on tamoxifen, in fact it's used in some countries to stimulate egg production in fertility treatment, but doctors advise against pregnancy while on it because of the chance of birth defects. You didn't mention if you binge eat before or after you take these medications. A greater proportion of women in the tamoxifen group reported having … 70, No. Animal studies of doses at or below equivalent human doses have revealed evidence of fetotoxicity, lower incidence of implantation, and an increased incidence of low birth weight. "Any young woman, before she undergoes chemotherapy, needs to see an endocrinologist to discuss fertility," says Dominguez. Additional research is under way to examine the impact of particular antidepressants on tamoxifen metabolism, and may provide additional guidance once published. AU TGA pregnancy category: B3 US FDA pregnancy category: D Comments: -This drug can harm a developing fetus.-Women should be advised not to become pregnant while taking this drug or within 2 months of discontinuing therapy and should use barrier or nonhormonal contraceptive measures if sexually active. In addition, it can also help to preserve fertility during breast cancer treatment. Tamoxifen Pregnancy Warnings. There are no controlled data in human pregnancy; however, the manufacturer reports spontaneous abortions, birth defects, fetal deaths, and vaginal bleeding associated with this drug during pregnancy.Breastfeeding is not recommended during use of this drug.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Many commonly used antidepressants are CYP2D6 inhibitors, thus clinicians and patients must consider possible interactions when using these treatments in women taking tamoxifen. However, research shows that tamoxifen is less effective in the treatment of breast cancer in post-menopausal women in comparison to aromatase inhibitors. It should be taken at the same time each day and can be taken either with or without food, depending on the individual's preference. "And I'm going to be comfortable doing that. This fertility drug has been shown to stimulate the ovaries when taken on a short-term basis. There is a 10% risk of having twins associated with tamoxifen … "We can now tell [premenopausal patients] that clinical evidence shows that 10 years [of tamoxifen] is superior to 5 years," Dr. Ravdin said. 2009 Dec;70(12):1688-97. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Forrester on dosage for elavil: Both of these medications can give you the munchies. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. Breast Cancer Patients Get Safe Fertility TreatmentJan. While there are many that are problematic in this regard, there are several options that are believed to be safe. In a pooled analysis of data from participants in 20 clinical trials, women with estrogen receptor-positive breast cancer who were assigned to receive about 5 years of adjuvant treatment with tamoxifen had a lower risk of recurrence in the 15 years after starting treatment than women who did not receive tamoxifen. Summary. Trials are currently trying to determine the when tamoxifen should be taken following breast cancer surgery; most doctors currently prescribe the drug for five years after surgery, while in other cases it can be prescribed for two years, or in some cases indefinitely. Consequently, any co-administered agent that inhibits this enzyme will reduce the conversion of tamoxifen to endoxifen, thereby potentially reducing the efficacy of tamoxifen as a breast cancer therapy (Jin et al, 2005). Nolvadex can also increase a woman's chances of getting pregnant; however, in this regard, tamoxifin is less effective, resulting in pregnancy in 30 to 35% of all cases. 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