Clindamycin is a powerful antibiotic usually reserved for very serious bacterial infections – of the lungs, skin, blood, female reproductive organs and other internal organs. Therefore, although relevant clinical trials or animal studies were preferred, this review is mainly based on experimental models, historical observational studies, non-randomized clinical trials and the guidelines of expert societies.In the management of bone and joint infections, the selection of antibiotic regimens and the duration of antibiotic therapy vary depending on the clinical setting and the treatment approaches available.The optimum duration of antibiotic treatment for bone and joint infections remains unknown because this has never been studied in prospective randomized studies.Several factors should be considered when selecting oral antibiotics to treat bone and joint infections. These include the type of infection, the extent of debridement when applicable, the antibiotic susceptibility of the pathogen, antibiotic penetration into the bone and joint tissues, oral bioavailability and cost. Each article was assessed for its clinical relevance and the quality of its methodology. Propionibacterium spp. OR . All rights reserved. C efazolin 2 g (3 g if greater than 120 kg) IV once Known MRSA colonization : New developments in diagnosis and treatment of infection in orthopedic implantsSystematic review and meta-analysis of antibiotic therapy for bone and joint infectionsAntibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials?Antibiotics for treating chronic osteomyelitis in adultsAntibiotic treatment of Gram-positive bone and joint infectionsAntimicrobial agents in orthopaedic surgery: prophylaxis and treatmentDiagnosis and treatment of infections associated with fracture-fixation devicesSpondylodiscitis: update on diagnosis and managementDiagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of AmericaRole of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Search for other works by this author on:
Epidemiology. Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of
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Adults: Preferred alternative if severe β-lactam allergy Optional oral regimens in combination with IV therapy: Neomycin. This tool may not cover all possible drug interactions. Oral agents are often used after an initial course of parenteral antibiotic treatment. It carries an FDA black-box warning to alert doctors and patients about possible adverse effects, including swelling of the face and tongue and serious skin reactions.
However, the majority of the articles were case reports or observational studies, and only a few were randomized clinical trials. Long-term antibiotic therapy, combined with appropriate surgery and the removal of prostheses, is required. II. The most common organisms causing bone and joint infections are staphylococci, including Despite the paucity of large prospective randomized clinical trials evaluating the efficacy and safety of oral therapy, and the heterogeneity of bone and joint infections, recent systematic reviews show that oral therapy is as effective as parenteral therapy provided that the microorganisms are susceptible to the agents used.We searched Medline for articles published in English. In the presence of a foreign body, there are slow-growing or adherent organisms in biofilms, against which antibiotic efficacy is diminished.Antibiotic bone penetration is also an important factor to consider, especially in the treatment of orthopaedic implant-associated infection, because it often has bone sequesters and an established biofilm.Whether monotherapy or combination therapy is more effective in staphylococcal bone and joint infections, especially implant-associated infections, remains unanswered.