Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.The chemical name for clindamycin palmitate hydrochloride is Methyl 7-chloro-6, 7, 8-trideoxy-6-(1-methyl-Cleocin Pediatric Flavored Granules contain clindamycin palmitate hydrochloride for reconstitution. Therefore, it should be used with caution in patients receiving such agents.Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin. Both tests were negative.Fertility studies in rats treated orally with up to 300 mg/kg/day (approximately 1.6 times the highest recommended adult human oral dose based on mg/mIn clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters, has not been associated with an increased frequency of congenital abnormalities. Clindamycin will not work for colds, flu, or other virus infections. Serum levels have been uniform and predictable from person to person and dose to dose.Multiple-dose studies in neonates and infants up to 6 months of age show that the drug does not accumulate in the serum and is excreted rapidly. Inactive ingredients: artificial cherry flavor, dextrin, ethylparaben, poloxamer, simethicone, compressible sugar.Blood level studies comparing clindamycin palmitate HCI with clindamycin hydrochloride show that both drugs reach their peak active serum levels at the same time, indicating a rapid hydrolysis of the palmitate to the clindamycin.Serum level studies with clindamycin palmitate HCI in normal pediatric patients weighing 50 to 100 lbs given 2, 3 or 4 mg/kg every 6 hours (8, 12 or 16 mg/kg/day) demonstrated mean peak clindamycin serum levels of 1.24, 2.25 and 2.44 mcg/mL respectively, one hour after the first dose. In the presence of strong CYP3A4 inducers such as rifampicin, monitor for loss of effectiveness.Long term studies in animals have not been performed with clindamycin to evaluate carcinogenic potential. Inactive ingredients: artificial cherry flavor, ethylparaben, pluronic F68, simethicone, sucrose.Blood level studies comparing clindamycin palmitate HCl with clindamycin hydrochloride show that both drugs reach their peak active serum levels at the same time, indicating a rapid hydrolysis of the palmitate to the clindamycin.Serum level studies with clindamycin palmitate HCl in normal pediatric patients weighing 50-100 lbs given 2, 3 or 4 mg/kg every 6 hours (8, 12 or 16 mg/kg/day) demonstrated mean peak clindamycin serum levels of 1.24, 2.25 and 2.44 mcg/mL respectively, one hour after the first dose. Clindamycin is bacteriostatic.Resistance to clindamycin is most often caused by modification of specific bases of the 23S ribosomal RNA. This medicine may be given to patients who have had an allergic reaction to penicillin. Because of the risk of colitis, as described in the To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cleocin Pediatric and other antibacterial drugs, Cleocin Pediatric should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum.Pharmacokinetic studies in elderly volunteers (61 to 79 years) and younger adults (18 to 39 years) indicate that age alone does not alter clindamycin pharmacokinetics (clearance, elimination half-life, volume of distribution, and area under the serum concentration-time curve) after IV administration of clindamycin phosphate. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. 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