doctor or pharmacist) know that you are taking these medicines together. If you experience weakness, tiredness, dizziness, irregular heartbeat, confusion, anxiety, nervousness, difficulty sleeping, or problems urinating, contact your doctor. Ther Drug Monit 1997 Feb; 19(1):71-3. doctor or pharmacist) for more information.Valproic acid may slow down how quickly your liver processes your antidepressant.The amount of antidepressant in your blood may increase and cause more side effects than normal.Let your healthcare professionals (e.g. good lunck Answered on Sep 9, 2014 Contact your healthcare professional (e.g. Please enable it to take advantage of the complete set of features! Clomipramine is less toxic in over-dose* than most other TCAs (nortriptyline may be the least toxic TCA) and about the same as venlafaxine [25, 56-58]. Anafranil (clomipramine) effectively treats obsessive-compulsive disorder (OCD), but has potentially intolerable side effects. Name must be less than 100 characters Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. This site needs JavaScript to work properly. * The Fatal toxicity index (FTI) is the number of deaths per million prescriptions issued in a defined population. CONCLUSION: As this study indicates, a rapid onset of action is one of the advantages of this combination. Anafranil (clomipramine) is an SNRI (selective norepineprhine reuptake inhibitor where Nortriptyline is a tricyclic anti depressant. Wiley 1997 Mar;154(3):396-401. doi: 10.1176/ajp.154.3.396.Diniz JB, Shavitt RG, Fossaluza V, Koran L, Pereira CA, Miguel EC.J Clin Psychopharmacol. 2011 Dec;31(6):763-8. doi: 10.1097/JCP.0b013e3182367aee.Barr LC, Goodman WK, Anand A, McDougle CJ, Price LH.Am J Psychiatry. J Clin Psychiatry. Status epilepticus associated with the combination of valproic acid and clomipramine. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Moderate. These medicines may cause some risk when taken together. Unable to load your collection due to an error Improves mood. This study supports further investigation of the noradrenergic-serotonergic hypothesis in … Anafranil (clomipramine) vs nortrip: hard to say since they are two different classes of anti depressants. 2006 Apr;67(4):600-10. doi: 10.4088/jcp.v67n0411.J Clin Psychiatry. Unable to load your delegates due to an error 1997 Sep;154(9):1293-5. doi: 10.1176/ajp.154.9.1293. doi: 10.1046/j.1365-2710.1998.00156.x. Helps control obsessive or compulsive behaviors. doi: 10.1046/j.1365-2710.1998.00156.x. COVID-19 is an emerging, rapidly evolving situation. It may be necessary to adjust the dose of your antidepressant.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. This information is generalized and not intended as specific medical advice. Wiley The SNRI may be better tolerated but no dose to dose equivalency is known. Clipboard, Search History, and several other advanced features are temporarily unavailable. clomipramine and nortriptyline showed a significant superiority over clomipramine alone in the treatment of OCD. Pamelor (nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain, but may take 6 to 8 weeks to feel the full effects on your mood. It’s funny because old school tricyclics like Clomipramine (and Nortriptyline) are supposed to target norepinephrine receptors that influence motivation and apathy. Being on Clomipramine / Anafranil all those years basically kept my head above water but I was still struggling greatly with my day to day depression. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. 1999 Feb;60(2):101-6. doi: 10.4088/jcp.v60n0206.Am J Psychiatry.