In total, 186 patients completed the double-blind treatment period. If you have any problems planning when to take your medicines speak with your doctor or pharmacist for advice.The main side-effects of colesevelam are wind and constipation.Colesevelam works in the body as a bile acid sequestrant. Advise patients to take oral contraceptives at least 4 hours prior to taking colesevelam hydrochloride The safety and effectiveness of colesevelam hydrochloride as monotherapy or in combination with a statin were evaluated in children, 10 to 17 years of age, with HeFH Due to tablet size, colesevelam hydrochloride for oral suspension is recommended for use in the pediatric population. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For patients with difficulty swallowing tablets, use colesevelam hydrochloride for oral suspension.Colesevelam hydrochloride may decrease the absorption of fat-soluble vitamins A, D, E, and K. Patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins may be at increased risk when taking colesevelam hydrochloride. Nitroglycerin works by relaxing the muscles surrounding blood vessels (arteries and veins) and so helps more blood and oxygen reach the heart while reducing its work load. The enzymatic action of type 5 phosphodiesterase (PDE5) is the primary mechanism for inactivation of cGMP, the downstream mediator of the vasodilating agent nitric oxide (NO) (Lugnier, 2006). They must be instructed to allow the nitroglycerin to dissolve in their mouth and allow their oral mucosa to absorb the drug. Do not drive yourself and call your local emergency services number if necessary. Do not use more than 3 sprays in a 15-minute period.Swallow the extended-release capsule whole. * For triglycerides, median % change from baseline.Values represent LS mean. You can opt out at any time or find out more by reading our Exposures at 1 g/kg/day were 5 times the human exposure at 3.75 g/day MRHD, based on body surface area (mg/mIn pregnant rats given oral gavage doses of 0.1, 0.3, 1 g/kg/day colesevelam hydrochloride from gestation day 6 through lactation day 21 (weaning), no adverse effects on survival and development were observed. The table below contains some of the most common ones associated with colesevelam. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Dose adjustments are not required when colesevelam hydrochloride is administered to children 10 to 17 years of age.Colesevelam hydrochloride has not been studied in children younger than 10 years of age or in premenarchal girls. The mechanism by which Welchol (colesevelam HCl) improves glucose metabolism is unknown. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.Never take more than the prescribed dose. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.The presence of other medical problems may affect the use of nitroglycerin. If you have any problems planning when to take your medicines speak with your doctor or pharmacist for advice.The main side-effects of colesevelam are wind and constipation.Colesevelam works in the body as a bile acid sequestrant. The mean LDL-C reductions were 18%, 15%, and 18% for the 3 dosing regimens, respectively. Advise patient to not take colesevelam hydrochloride oral suspension in its dry form.Advise females of reproductive potential that colesevelam hydrochloride may reduce the effectiveness of oral contraceptives, and to take oral contraceptives at least 4 hours before taking colesevelam hydrochloride Nitroglycerin sublingual tablet is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.Nitroglycerin is most commonly administered as a tablet that is absorbed sublingually. You may become dizzy, lightheaded, or faint soon after using a tablet or spray, so it is safer to sit rather than stand while the medicine is working. Nitroglycerin is also called glyceryl trinitrate, is used to prevent attacks of chest pain (angina) caused by coronary artery disease (narrowing of the blood vessels that supply blood to the heart). You may feel burning or tingling in your mouth as the tablet dissolves. Never give it to other people even if their condition appears to be the same as yours.Do not keep out-of-date or unwanted medicines. In the US general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.There are no adequate and well-controlled studies of colesevelam hydrochloride use in pregnant women. Do not take more than 3 packets in 15 minutes. This dose was approximately 50 times the maximum recommended human dose of 4.5 g/day, based on body weight, mg/kg.