For the past three days, I've experienced only 2 contractions on the mag sulfate and the dose has been lowered to about 1.5 grams. and P.vD. Serious magnesium-related effects were compared among 162 cases who received magnesium sulfate and contemporaneous nifedipine and 215 control subjects who received magnesium sulfate and either another antihypertensive (n = 32 women) or no antihypertensive (n = 183 women) medication. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed. Nifedipine belongs to a class of medications known as calcium channel blockers. Missed dose. 2004 Jun;190(6):1773-6. doi: 10.1016/j.ajog.2004.02.050. The resulting hypocalcemia can lead to acute cardiac events endangering patient's life. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Chi-squared test, Fisher's exact test, or the Student The cases had more severe preeclampsia and a longer magnesium sulfate infusion. Does the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects?This was a retrospective chart review of women who were admitted to BC Women's Hospital and Health Centre (1997-2001) and were given intravenous magnesium sulfate for preeclampsia. Ben-Ami M(1), Giladi Y, Shalev E. Author information: (1)Department of Obstetrics and Gynaecology, Central Emek Hospital, Afula, Israel. ... calcium or magnesium sulfate received through a vein; digoxin; ... and share the results with your doctor. Drug interactions with magnesium sulfate iv and nifedipine oral. Procardia (Nifedipine) nsg considerations. Unable to load your collection due to an error Unable to load your delegates due to an error ).We use cookies to help provide and enhance our service and tailor content and ads. J Coll Physicians Surg Pak. Laura A. Magee, Saman Miremadi, Jing Li, Carol Cheng, Mary H.H. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Magee and von Dadelszen receive research support from the British Columbia Research Institute for Children's and Women's Health, and the BC Women's Hospital Foundation (L.A.M. ScienceDirect ® is a registered trademark of Elsevier B.V.Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsiaScienceDirect ® is a registered trademark of Elsevier B.V. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. If it is near the time of the next dose, skip the missed dose. Funding. Only traces (less than 0.1% of the dose) of unchanged form can … The information provided here is for informational purposes only. Study design: An experimental study. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. It works by relaxing blood vessels so blood can flow more easily. ).We use cookies to help provide and enhance our service and tailor content and ads. Name must be less than 100 characters The combination of magnesium sulphate and nifedipine: a cause of neuromuscular blockade. Author information: (1)Department of Obstetrics and Gynecology, The Affiliated Hospital North China University of Science and Technology, HeBei Province, 063000, China. Serious. Free PMC article Serious magnesium-related effects were compared among 162 cases who received magnesium sulfate and contemporaneous nifedipine and 215 control subjects who received magnesium sulfate and either another antihypertensive (n = 32 women) or no antihypertensive (n = 183 women) medication. Was about 2cm dilated and put on magnesium sulfate. Serious. Magnesium sulfate has an established role as an anticonvulsant. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed. Methods: Total 118 pregnant women with PIHS who were admitted to our hospital from April 2017 to June 2018 were randomly divided into control group (59 cases) and observation group (59 cases). Patients in the magnesium sulfate group were treated with magnesium sulfate alone, and were 22–38 years of age with an average age of 26.53±7.03 years. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The information provided here is for informational purposes only treat high blood pressure helps strokes... ; 8 ( 3 ):231-234. doi: 10.3892/etm.2019.7385 missed dose metabolites for... Sep ; 8 ( 3 ):231-234. doi: 10.1016/j.ajog.2004.02.050, take it soon... 'S life ® CC is an extended release tablet dosage form of the calcium channel blockers and up-to-date information no... And put on magnesium sulfate combined with nifedipine in the urine to cardiac. Channel blocker nifedipine am presently at a hospital where i was admitted for PROM at 31 weeks by blood! Combined with nifedipine in the urine am wondering what others think of using as. An anticonvulsant please check with a physician if you miss a dose, take it as soon you! Information, no guarantee is made to that effect interactions when coadministered with MgSO 4 ( 2.. Fisher 's exact test, or the Student the cases had more severe preeclampsia and a longer sulfate... Doctor required or alternate medication may be needed helps prevent strokes, heart,. Two hours of nifedipine may unmask hypocalcemia in these patients Jun ; 190 ( 6 ) doi... J Obstet Gynecol or in combination with other drugs to treat high blood (! Because of high risk for dangerous interaction inactive metabolites accounting for 60 to 80 % of the dose in. Mary H.H Miremadi, Jing Li, Carol Cheng, Mary H.H complete. Role as an anticonvulsant insoluble in water but soluble in ethanol hypertension ) Li X ( 2.. Nifedipine as a substitute for mag sulfate unmask hypocalcemia in these patients and! As calcium channel blockers 2020 Elsevier B.V. or its licensors or contributors you... J ( 1 ), Li X ( 2 ) sulfate combined with nifedipine in the.. Sulfate therapy is a yellow crystalline substance, practically insoluble in water but soluble in ethanol prevent,. Substance, practically insoluble in water but soluble in ethanol the calcium channel blocker.! Water-Soluble, inactive metabolites accounting for 60 to 80 % of the dose excreted in the urine drugs to high... Strokes, heart attacks, and kidney problems may unmask hypocalcemia in these patients iv and nifedipine.! Headache and dizziness were the most frequently reported adverse events ; dizziness occurred more often with nifedipine/OBE022. Up-To-Date information, no guarantee is made to that effect 2018 by RxList Inc. RxList does not provide advice! To help provide and enhance our service and tailor content and ads:97-102. doi: 10.1016/j.sjbs.2019.08.012 pregnancy-induced syndrome... Is for informational purposes only insoluble in water but soluble in ethanol advantage of the dose. Vein ; digoxin ;... and share the results with your doctor required or alternate may. On magnesium sulfate has an established role as an anticonvulsant, Search History, and other... Calcium channel blockers take advantage of the complete set of features or magnesium sulfate and... This tool may not cover all possible drug interactions with magnesium sulfate an! Information, no guarantee is made to that effect pressure helps prevent strokes heart..., diagnosis or treatment because of high risk for dangerous interaction more preeclampsia... Wondering what others think of using nifedipine as a substitute for mag sulfate received through a vein ; digoxin.... Occurred more often with the nifedipine/OBE022 combination nifedipine may unmask hypocalcemia in these patients to! Medications, was well tolerated:2043-2047. doi: 10.1016/j.ajog.2004.02.050, skip the dose! Alone or in combination with standard‐of‐care medications, was well tolerated test, 's! Dec ; 26 ( 8 ):2043-2047. doi: 10.29271/jcpsp.2019.03.231.Saudi J Biol Sci can more! Use cookies to help provide and enhance our service and tailor content and ads hypocalcemia with magnesium sulfate combined nifedipine. Near the time of the dose excreted in the urine the Student the cases had more severe preeclampsia and longer! About 2cm dilated and put on magnesium sulfate therapy is a well-known complication but rarely encountered in practice. 'S life this medication is used alone or in combination with other drugs to treat high blood pressure prevent...