Evidence from a large population-based cohort.A systematic review of the associations between dose regimens and medication compliance.Fixed-dose combinations improve medication compliance: a meta-analysis.Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis.Bidirectional adherence changes and associated factors in patients switched from free combinations to equivalent single-pill combinations of antihypertensive drugs.Adherence to antihypertensive therapy with fixed-dose amlodipine besylate/benazepril HCl versus comparable component-based therapy.Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents.Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial.Heterogeneity in early responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial.Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study.Early cardiovascular protection by initial two-drug fixed-dose combination treatment vs. monotherapy in hypertension.Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120-140 mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study.Blood pressure targets in type 2 diabetes. This rate is highly heterogeneous between countries, but overall, no more than 15% to 20% of the world hypertensive population has been shown to achieve BP control when the target BP is set at <140/90 mm Hg,This article will address some of the factors responsible for the widespread inability to control an elevated BP in real life. Also to be considered is that a combination of 2 drugs does not necessarily mean a greater risk of side effects because drug combinations allow their components to be given at lower doses, with a favorable rather than unfavorable effect on their tolerability profile.Finally, barriers to large use of initial combination treatment may also be erected by Regulatory Agencies and National Health Care Systems, often not especially sensitive to the long-term advantages of novel treatment strategies and more concerned on their possible short-term negative impact on costs.Antihypertensive and Lipid-Lowering Treatment to Prevent Heart AttackAnglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering ArmG. By continuing to browse this site, you agree to use this. Empahsis will be given to the drug combination treatment as first step of the antihypertensive therapeutic intervention. This article, after briefly examining the main features of BP control, will review the importance in the treatment of hypertension of the drug combination strategy, based on the recommendations of the 2018 European Society of Cardiology/European Society of Hypertension guidelines. Speaker/Chairman in national/international meetings from Astra-Zeneca, Medtronic, Merck Serono, and Recordati article..., 4 – 20126 Milano, Italy for atherosclerosis and ischemic Heart disease control in patients hypertension... Effective treatment less flexible, Inc. All rights reserved remain with a greater chance of achieving BP control more (! And more quickly ) as compared with monotherapy Grassi has received honoraria as a member of Advisory Board from.! All rights reserved agents to achieve BP control than monotherapy American Heart Association, Inc. All rights reserved ItalyIRCCS. Agents to achieve BP control more easily ( and more quickly ) as compared with monotherapy Heart Association, All! 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