cyclophosphamide gonadal toxicity uroxatral

eCollection 2020.Clin J Am Soc Nephrol. 2015 Jul;11(7):379-89. doi: 10.1038/nrneurol.2015.85. The data indicate that there is no hard evidence to support the superiority of long-term i.v. Please enable it to take advantage of the complete set of features! Autoimmune diseases such as SLE also influences fertility independent of CYC exposure. Epub 2018 Jul 24.Nat Rev Neurol. 2910 0 obj <> endobj xref Monthly i.v. 0000011278 00000 n h�b```f``-f`e`�Tef@ a6v��.�Nm`�&��f0�k( 0000000016 00000 n RESULTS: In lupus patients treated with cyclophosphamide, 60% suffered from POF and hypergonadotropic amenorrhea. 0000012202 00000 n For patients with lupus nephritis, a 24-month course of intravenous cyclophosphamide has been advocated as the 'golden' standard of therapy. This regimen is associated with a high risk of persistent amenorrhoea in women or azoospermia in men. ��V@��\�A�@m@F�Aq$��*�TRPP--$�%(��⒖��VRR66�H��$A@&�� )`s@ Mok CC, Ying KY, Ng WL, Lee KW, To CH, Lau CS, Wong RW, Au TC.Am J Med. Therefore, patients with SLE and the wish to have a baby should not be primarily treated with such a regimen. Transient cardiac toxicity attributed to cyclophosphamide occurs in up to 45% of BMT recipients. In addition a brief overview is given of the literature on treatment of lupus nephritis. 0000007239 00000 n Name must be less than 100 characters 0000018014 00000 n The risk of infertility is thus an important issue when discussing treatment options in patients with SLE. In general, … RISK FACTORS FOR MALE GONADAL TOXICITY WITH CYC As with females, the severity and risk of gonadal toxicity from CYC exposure is dependent on gonadal activity at the time of treatment (prepubertal vs. sexually mature males), and total cumulative dose. Therapy with alkylating agents, such as cyclophosphamide, can be associated with irreversible gonadal toxicity in male survivors of adult cancer. , 1977; Kallen e t a / . Background: Cyclophosphamide has been used increasingly to treat patients with nonmalignant diseases like primary glomerulonephritis and systemic vasculitis. , 1974; Pennisi e t a / . therapy. 0000004019 00000 n 0000002560 00000 n To the authors's knowledge the effect of high dose therapy with cyclophosphamide during childhood on adult testicular reproductive and endocrine function has not been established. 2910 32 2012 Jun;2(2):163-171. doi: 10.1038/kisup.2012.16. 0000032273 00000 n trailer <<2DE046835C1844C89E90BCBFAD5B3822>]/Prev 490873/XRefStm 2081>> startxref 0 %%EOF 2941 0 obj <>stream doi: 10.1016/j.rdc.2009.12.010.Autoimmun Rev. Autoimmune diseases such as SLE also influences fertility independent of cyclophosphamide exposure. 0000002081 00000 n 2006 Apr;5(4):269-72. doi: 10.1016/j.autrev.2005.10.001. doi: 10.1016/j.amjmed.2005.08.045.Rheum Dis Clin North Am. Others, however, demonstrated the presence of gonadal toxicity by sperm analysis, testicular biopsy, and l o r gonadal hormonal assay, undertaken at the time of puberty or after puberty, even after relatively short-term low-dose therapy (2 m g l k g l d a y for90 days) (Hyman and Gilbert, 1972; Penso e t a / . GONADAL TOXICITY OF CYCLOPHOSPHAMIDE Cyclophosphamide-induced amenorrhoea in women In table 2an overview is given of six studies that have documentedthe risk of persistent amenorrhoea in patients with SLE after treatment with cyclophosphamide in cumu-lativedosages of 12 to 25 g.1,3-7The mean age of the patients was 28 years. Clipboard, Search History, and several other advanced features are temporarily unavailable. �)F��2��1�V�S'Aq�:@|��=��g��/1��X1� �6��@Z��a��vd`��x��. van Zuiden Communications , 1975; Lentz e t a / . 0000005481 00000 n 0000032393 00000 n 2010 Feb;36(1):99-108, viii. h��1 0ð4�)��:L�jo��4��C 0000010424 00000 n Cyclophosphamide-induced gonadal toxicity: a treatment dilemma in patients with lupus nephritis? 0000009502 00000 n In this article I have summarised the information on cyclophosphamide-induced gonadal toxicity. 0000005569 00000 n 2008 Nov;52(5):887-96. doi: 10.1053/j.ajkd.2008.06.017.Case Rep Rheumatol. '"�V@� 0000005078 00000 n Epub 2015 Jun 2.Ishikura K, Matsumoto S, Sako M, Tsuruga K, Nakanishi K, Kamei K, Saito H, Fujinaga S, Hamasaki Y, Chikamoto H, Ohtsuka Y, Komatsu Y, Ohta T, Nagai T, Kaito H, Kondo S, Ikezumi Y, Tanaka S, Kaku Y, Iijima K; Japanese Society for Pediatric Nephrology; Japanese Society for Pediatric Nephrology.Clin Exp Nephrol. 0000047323 00000 n 0000271552 00000 n ,1973). The cumulative dosage of 0000035434 00000 n The risk of amenorrhoea ranged from 27 to 60%. This report concerns our own … 0000000953 00000 n 0000002309 00000 n Epub 2005 Oct 27.Cigni A, Faedda R, Atzeni MM, Pileri PV, Alagna S, Rovasio P, Satta AE, Loi MR, Sini A, Satta V, Masala A.Am J Kidney Dis. 0000013926 00000 n Thus long-term side effects like gonadal toxicity have become an important issue. 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