PHSteinberg Further studies using larger groups of patients are needed to evaluate the efficacy of pulse intravenous cyclophosphamide in pemphigus vulgaris.  JRFauci Rosenberg Conclusions Intravenous pulse cyclophosphamide may be an alternative treatment option in patients with pemphigus recalcitrant to standard therapy.  DTYamada  OWechsler  PMintz Intravenous pulse cyclophosphamide, which may be more efficacious and less toxic than oral immunosuppressives, has been used successfully in the treatment of pemphigus.To review 9 patients with severe or previously recalcitrant pemphigus who were treated with intravenous pulse cyclophosphamide therapy.Six of the 9 patients responded to therapy, with 2 patients achieving remission from skin lesions. The efficacy of cyclophosphamide pulse therapy was evaluated in pemphigus vulgaris (2 males and 4 females aged 34 to 47 years) and in a 56-year-old male with pemphigus foliaceus.  RY  ACambazard S2 Guideline for diagnosis and treatment – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Journal of the European Academy of Dermatology and Venereology, Randomized double‐blind study of the effect of dexamethasone and methylprednisolone pulse in the control of rheumatoid arthritis flare‐up: a preliminary study, Treatment of pemphigus vulgaris and pemphigus foliaceus, Stevens‐Johnson Syndrome with Idiopathic Thrombocytopenic Purpura Treated with Dexamethasone Pulse Therapy, Immediate and Delayed Complications of Dexamethasone Cyclophosphamide Pulse (DCP) Therapy, British Association of Dermatologists' Management Guidelines, Dexamethasone-Cyclophosphamide Pulse Therapy in Pemphigus, Pulsed intravenous cyclophosphamide and methylprednisolone therapy in refractory pemphigus, Corticosteroid/cyclophosphamide pulse treatment in South African patients with pemphigus, Remisión clínica completa prolongada en pacientes con pénfigo vulgar grave después del tratamiento con ciclos intravenosos de ciclofosfamida, Prolonged Complete Clinical Remission in Patients With Severe Pemphigus Vulgaris After Cycles of Intravenous Cyclophosphamide, The use of oral cyclophosphamide with dexamethasone pulse therapy in the treatment of pemphigus vulgaris, Treatment of Widespread Alopecia Areata in Young Patients with Monthly Oral Corticosteroid Pulse, Intravenous dexamethasone vs methylprednisolone pulse therapy in the treatment of acute endothelial graft rejection, Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy, Journal of the European Academy of Dermatology and Venereology, Guidelines for the management of pemphigus vulgaris, Efficacy and Safety of Cyclophosphamide, Azathioprine, and Cyclosporine (Ciclosporin) as Adjuvant Drugs in Pemphigus Vulgaris, Treatment of pemphigus vulgaris.  JCSteinman All Rights ReservedAdjuvant therapy is commonly used in pemphigus to mitigate the high morbidity and mortality associated with the use of corticosteroids and improve disease control.  JJorgensen Abstract

 H-JD'Cruz
1.  VLustig All patients had a complete blood cell count, serum chemistry screen, urinalysis, and, if female, a pregnancy test before beginning treatment.  BMeynadier  AJimenez-Balderas  BJBalow 5,6 Boumpas Complete remission off therapy was achieved in 83 patients (30%), and 152 patients (55%) had complete remission on therapy.

 JSThanzama  KM Cyclophosphamide pulse therapy in Wegener's granulomatosis. Patient 9 had an excellent response to therapy after 8 pulse doses of IV cyclophosphamide and remained clear of disease for 1 year; however, the patient's disease recently began to flare, prompting a resumption of pulse cyclophosphamide therapy.Cyclophosphamide is an alkylating agent that disrupts cell growth and mitotic activity by cross-linking DNA,Although intravenous pulse cyclophosphamide is associated with fewer adverse reactions than oral therapy, teratogenicityIntravenous pulse cyclophosphamide has been used in the treatment of several diseases, including neuropsychiatric lupus erythematosus,Other modalities used for the treatment of pemphigus have had variable response rates that compare favorably with that of our patients.  JP Cyclophosphamide toxicity: characterizing and avoiding the problem.
 RD Treatment of pemphigus vulgaris with pulse intravenous cyclophosphamide.  BWasserstrum Sondergarrd Patient Demographic Information Before Treatment With Pulse Cyclophosphamide*Bystryn  GRV Short term effects of intravenous pulses of cyclophosphamide in the treatment of connective tissue disease crisis. Bystryn  GEMcCabe Ahmed  B  GWolff Surrinder  MD Systemic lupus erythematosus: emerging concepts, I: renal, neuropsychiatric, cardiovascular, pulmonary, and hematologic disease.  ERB Teratogenic effects of first-trimester cyclophosphamide therapy.  JGuilhou Treatment of nine cases of pemphigus vulgaris with cyclosporine.  SSandbank