I did have one cup of regular coffee and it seemed to make me a little more anxious..... or is it just in my head? Cymbalta has active ingredients of duloxetine hydrochloride. See what they are, when they happen and for whom. eHealthMe is studying from 2,738 Caffeine users now. Cymbalta and caffeine. Select one or more newsletters to continue. 1 doctor answer. Do not stop using any medications without first talking to your doctor. Both caffeine and Cymbalta alter the levels of neurotransmitters in the brain. Drug interactions are reported among people who take Caffeine and Cymbalta together. Medical research https://www.ncbi.nlm...pubmed/24933334 Coffee increase serotonin, norepinephrine and dopamine and increases the effect of the Cymbalta. Let your doctor know if your condition changes or you experience increased side effects of DULoxetine such as nausea, dry mouth, insomnia, drowsiness, constipation, or any unusual symptoms. That somehow caffeine does not metabolize … We only included the generic names of these drugs and some can be found in pills that have the substance combined with other drugs. High doses of caffeine may keep Cymbalta from being removed from your body, allowing high levels to build up. Caffeine may also change the effectiveness of Cymbalta's treatment of psychiatric disorders, by altering the balance of neurotransmitters. Chris Daniels covers advances in nutrition and fitness online. Let your doctor know about your caffeine intake when she prescribes Cymbalta. It is often used in depression. Best wishes, Laurie In addition, you may have an increased risk of developing a rare but serious condition associated with the use of DULoxetine and similar medications called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Your doctor may prescribe Cymbalta for major depressive disorder, generalized anxiety disorder, chronic pain, diabetic neuropathy or a purpose not listed. Coffee contains caffeine which is a stimulant and increases any existing anxiety and makes it worse. eHealthMe is studying from 126,517 Cymbalta users now. Cymbalta already has common side effects like nausea, insomnia, and dry mouth. * Approximation only. Side effects of Cymbalta include dry mouth, drowsiness, fatigue, nausea and constipation. I'm almost three weeks out since my last cymbalta capsule after being on it for 8 months. All rights reserved. Caffeine has active ingredients of caffeine. The study is created by eHealthMe based on reports of 52 people who take Caffeine and Cymbalta from the FDA, and is updated regularly. MayoClinic.com recommends that adults keep caffeine intake below 200 to 300 mg per day, or two to four cups of coffee. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Mixing Cymbalta & Caffeine - Cymbalta (duloxetine) - The I have heard Cymbalta and caffeine should not be mixed. That somehow caffeine does not metabolize properly. Drug interactions are reported among people who take Caffeine and Cymbalta together. You should avoid or limit the use of alcohol while being treated with DULoxetine. Anyone experience this while drinking coffee or sodas? Dr. James Rochester answered. The drug caffeine can sometimes have moderate to severe interactions with other medications a person may be taking.. Call your doctor immediately if you have fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, dark colored urine, or yellowing of the skin or the whites of your eyes, as these may be symptoms of liver damage. However, high doses of caffeine an have signifiant effects when taken with Cymbalta.Caffeine and cymbalta are broken down by the same enzymes in your liver: CYP450 1A2. Cut WAY back on caffeine--trying to eliminate altogher. 1-2 … Caffeine and Cymbalta Drug Interactions - Drugs.com A Moderate Drug Interaction exists between caffeine and Cymbalta.View detailed information regarding this drug interaction.Cymbalta oral : Uses, Side Effects, Interactions, Pictures Find patient medical information for Cymbalta oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.