endobj endobj endstream 66 ANEMIA Aranesp®*, Epogen®, Procrit®*, Neulasta®* None Reported ANTACIDS (H-2 Bockers, Proton Pump Inhibitors) ... Toprol-XL®*, Norvasc®*, Lisinopril®*, Furosemide*, Chlorthalidone, Digoxin, Clonidine, Propranolol CoQ10 Phosphorous Potassium Sodium Zinc Calcium Magnesium Vitamin B1 16 0 obj Four of those 12 cats were hypertensive before treatment, 3 remained hypertensive, and 1 was not hypertensive at any point after starting treatment. 43 0 obj /Length 10 0 R 13 0 obj H
���� ��L�@��f)C�`7XMV��j��ڭ���eu[=��[���f�����V���T\G 54 Pure red cell aplasia appears to be less common with darbepoetin than with epoetin usage. endobj /Length 51 0 R 25 0 obj However, because of the retrospective nature of this study and low number of animals observed, it is difficult to make dosage recommendations based on this study. For the purposes of this study, PCV and HCT were regarded as similar values. Be sure to follow your doctor's orders carefully. Check with your doctor right away if you start having dizziness, fainting spells, severe tiredness, chest pain, trouble with breathing, sudden or severe headache, or problems with vision, speech, or walking.When used in patients with certain types of cancer (eg, breast, cervix, lymphoid, lung, head, or neck cancer), darbepoetin alfa has shortened survival time and worsened the tumor or cancer in some patients. endobj x�+�2�37��P0 A ��P��D���B���B����P!9���������L��=�\�� �
� Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. 18 0 obj 15 0 obj <> Twelve cats (48%) had 1 or more potential adverse events noted.Survival data were available for all 25 cats in the study. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. stream Hypothesis/Objective: To evaluate the use of darbepoetin, a recombinant analog of human erythropoietin, to stimulate erythropoiesis, and to effectively treat anemia of kidney disease in cats. Darbepoetin alfa is used to treat severe anemia in these patients.Darbepoetin alfa is available only with your doctor's prescription.In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. x�+�2�3717V0 A ��P��D���L���B����P!9��������Q@1}Oc�|�@ ��
� 37 0 obj Darbepoetin is effective for treatment of anemia of kidney disease in cats. <> Eleven cats received iron dextran at a median of 41 days after starting darbepoetin, including 3 cats that had received a transfusion at the start of darbepoetin treatment and 1 cat that did not receive any iron product until iron dextran was administered at day 40. x�VwVs����6�6 endstream <> endobj x�VwVs�����2 Of these, 28 animals did not survive for 56 days, 10 were lost to follow‐up, and 2 had acute kidney injury. A starting dosage of 1.0 μg/kg SC once weekly seems to provide a better response than lower dosages, and iron supplementation is strongly recommended during darbepoetin treatment.The authors thank Karen Poeppel, LVT, Ella Mitelberg, LVT, and Jen Severence, LVT, for their work on this manuscript. endobj endobj /Length 16 0 R ANEMIA Aranesp®*, Epogen®, Procrit®*, Neulasta®* None Reported ANTACIDS (H-2 Bockers, Proton Pump Inhibitors) ... Toprol-XL®*, Norvasc®*, Lisinopril®*, Furosemide*, Chlorthalidone, Digoxin, Clonidine, Propranolol CoQ10 Phosphorous Potassium Sodium Zinc Calcium Magnesium Vitamin B1 Cats were excluded if they were treated with darbepoetin but did not have kidney disease. All nonresponder cats continued darbepoetin treatment until death.