Most drug interactions reducing or negating contraceptive activity are due to concomitant use of drugs having microsomal enzyme-inducing activity (e.g., some antibiotics, especially rifampicin, and anticonvulsants, including phenobarbital, phenytoin, and primidone. 7,8 Fortunately, patients can take other anticonvulsants and gabapentinoids with OCs safely with appropriate lab monitoring (see Table 1. PIP: In the very rare cases where a pregnancy occurs during oral contraceptive (OC) use, the blame is usually laid against the patient for having forgotten to take the pill. Gemfibrozil, ketoconazole, and birth control pills are among the medications that can cause rosuvastatin drug interactions. Evidence has started to accumulate to suggest that neither the patient nor the pill is at fault in some contraceptive failures. 1986;26 Suppl 1:7-17. Potential Drug Interactions ... al. Please enable it to take advantage of the complete set of features! 1981 Jan;21(1):46-61. doi: 10.2165/00003495-198121010-00003.Contraception. This site needs JavaScript to work properly. PIP: In the very rare cases where a pregnancy occurs during oral contraceptive (OC) use, the blame is usually laid against the patient for having forgotten to take the pill. 3. Imitrex is a selective serotonin receptor agonist (also called a triptan) and Topamax is an anticonvulsant. It works by narrowing blood vessels in the head, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. This site needs JavaScript to work properly. Oral contraceptives can affect women living with migraine differently. [Interactions of drugs with oral contraceptives]. Name must be less than 100 characters Unable to load your collection due to an error Sumatriptan oral tablets usually start working within 30 minutes, with the peak effect occurring within two to four hours. 2. Oral Contraceptives and Cyp Interactions). 1983 Jun;27(6):531-51. doi: 10.1016/0010-7824(83)90019-7.Foussard-blanpin O, Paillot-renaud P, Bruneau-bigot A.Xu Y, Gabriel K, Wang Y, Zhou Y, Eisele O, Vutikullird A, Mikol DD, Lee E.CNS Drugs. COVID-19 is an emerging, rapidly evolving situation. CBD does not produce any of the psychoactive responses and appears to block some of the effects of THC by acting as an antagonist at the cannabinoid receptors. Colesevelam — decreases blood concentrations of the COC by binding to COCs in the gut and reducing absorption. It is suggested that the effects of such interaction might be presented in terms of increased incidence of side effects, including water retention, diabetogenic effects, hypertension, and an increased risk of thromboembolic disorders. They have a relatively wide therapeutic index, and although a number of minor pharmacokinetic interactions have been observed, few are likely to be clinically significant. Oral contraception does not alter single dose saquinavir pharmacokinetics in women. Unable to load your delegates due to an errorClin Pharmacokinet. 2004 Mar;57(3):244-52. The following additional drug interactions may occur with combined oral contraceptives (COCs): Orlistat — advise women on what to do if they experience diarrhoea while taking orlistat. Use only if a clear diagnosis of migraine headache has been established. In the very rare cases where a pregnancy occurs during oral contraceptive use, the blame is usually laid against the patient for having forgotten to take the pill. This site needs JavaScript to work properly. Limitations of Use: 1. This is linked to fewer dips in iron levels while on birth control.