Dolutegravir + rilpivirine FDC is an oral tablet that contains two antiretroviral medicines: 1,3 dolutegravir 50 mg and ; rilpivirine 25 mg. Dolutegravir is an integrase strand transfer inhibitor (INSTI) that prevents HIV replication by stopping HIV DNA from integrating into the nucleus of the host cell. ©2018 WebMD, Inc. All rights reserved. We comply with the HONcode standard for trustworthy health information - Tell your doctor about all your current medicines and any medicine you start or stop using. You may report side effects to FDA at 1-800-FDA-1088.Some medicines can make dolutegravir and rilpivirine less effective when taken at the same time. It was the second in the class of integrase inhibitors to be approved by the U.S. Food and Drug Administration (FDA). Dolutegravir … ©2020 WebMD, Inc. All rights reserved.What are the possible side effects of dolutegravir and rilpivirine (Juluca)?What is the most important information I should know about dolutegravir and rilpivirine (Juluca)?What should I discuss with my healthcare provider before taking dolutegravir and rilpivirine (Juluca)?How should I take dolutegravir and rilpivirine (Juluca)?What should I avoid while taking dolutegravir and rilpivirine (Juluca)?What other drugs will affect dolutegravir and rilpivirine (Juluca)? Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Tivicay (dolutegravir) is an integrase inhibitor-class antiretroviral drug used in the treatment of HIV. Do not take two doses at one time.Get your prescription refilled before you run out of medicine completely.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Using dolutegravir and rilpivirine will not prevent your disease from spreading. Dolutegravir; rilpivirine is primarily metabolized and eliminated by the liver; however, no dosage adjustments are required for patients with mild or moderate hepatic impairment (Child-Pugh A or B). Keep the tablets in their original container, along with any packet or canister of moisture-absorbing preservative.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.Follow all directions on your prescription label and read all medication guides or instruction sheets. ©2018 WebMD, Inc. All rights reserved. Dolutegravir is also being studied in patients who are infected with HIV that is resistant to raltegravir or elvitegravir. Select one or more newsletters to continue. Dolutegravir is an antiviral medicine that is used with other medications to treat This medicine is for use in adults and children who weigh at least 66 pounds (30 kilograms).Dolutegravir may also be used for purposes not listed in this medication guide.Dolutegravir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Talk with your doctor about safe ways to prevent HIV transmission during sex. Use the medicine exactly as directed.Dolutegravir doses are based on weight in children. vitamin or mineral supplements that contain calcium or iron (but if you take dolutegravir with food, you can take these supplements at the same time).Many drugs can affect dolutegravir. Use the medicine exactly as directed.Always take this medicine with food, not with a meal replacement drink.Do not change your doses or medication schedule without your doctor's advice. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Some medicines can make dolutegravir much less effective when taken at the same time. Talk with your doctor about safe ways to prevent HIV transmission during sex. Dolutegravir and rilpivirine is for use only in people who have been successfully treated with other antiviral medications for at least 6 months.Dolutegravir and rilpivirine may also be used for purposes not listed in this medication guide.Taking dolutegravir during the first trimester of pregnancy may cause birth defects. This medicine is not a cure for HIV or AIDS.. Dolutegravir and rilpivirine is for use only in people who have been successfully treated with other antiviral medications for at least 6 months. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. This includes prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc.