Stability. UNSPECIFIED CAS registry number (Chemical Abstracts Service) 1051375-16-6. (4R,12aS)-N-[(2,4-difluorophenyl)methyl]-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (WHO)2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-,(4R,12aS)- (USAN)Important Notice: The Drugs.com international database is in BETA release. InChIKey=UGWJRRXTMKRYNK-VSLILLSYSA-M It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. Datasheets.
Consult with your healthcare professional before taking any medication.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Calculated molecular properties are available for small molecules and natural products (not peptides). 1Q1V9V5WYQ
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Dolutegravir demonstrated antiviral activity in cell culture against a panel of HIV-1 clinical isolates (3 in each group of M clades A, B, C, D, E, F, and G, and 3 in group O) with EC50 values ranging from 0.02 nM to 2.14 nM for HIV-1.
SODIUM (4R,12AS)-9-(((2,4-DIFLUOROPHENYL)METHYL)CARBAMOYL)-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO(1',2':4,5)PYRAZINO(2,1-B)(1,3)OXAZIN-7-OLATE2H-PYRIDO(1',2':4,5)PYRAZINO(2,1-B)(1,3)OXAZINE-9-CARBOXAMIDE, N-((2,4-DIFLUOROPHENYL)METHYL)-3,4,6,8,12,12A-HEXAHYDRO-7-HYDROXY-4-METHYL-6,8-DIOXO-, SODIUM SALT (1:1), (4R,12AS)-
Dolutegravir coadministered with dofetilide can result in potentially life-threatening adverse events. National Center for Advancing Translational Sciences (NCATS), For more info on each category see the Dolutegravir EC50 values against 3 HIV-2 clinical isolates in PBMC assays ranged from 0.09 nM to 0.61 nM. 1Q1V9V5WYQ ATC (Anatomical Therapeutic Chemical Classification) J05AX12. Chemical Formula. Glaxo Group, Slovakia; Glaxo Wellcome, Serbia; GlaxoSmithKline, Argentina; GlaxoSmithKline, Denmark; GlaxoSmithKline, Spain; GlaxoSmithKline, Croatia (Hrvatska); GlaxoSmithKline, Israel; GlaxoSmithKline, Malaysia; GlaxoSmithKline, New Zealand; GlaxoSmithKline, Turkey; GlaxoSmithKline Brasil, Brazil; ViiV Healthcare, Greece; ViiV Healthcare, Lithuania; ViiV Healthcare, Latvia; ViiV Healthcare, Norway; ViiV Healthcare, Poland; ViiV Healthcare, Romania; ViiV Healthcare, Slovenia; Viiv Healthcare UK, Cyprus; ViiV Healthcare UK Limited, IcelandViiV, Hungary; ViiV Healthcare, Switzerland; ViiV Healthcare, GermanyGlaxoSmithKline, Argentina; GlaxoSmithKline, Denmark; GlaxoSmithKline, Croatia (Hrvatska); GlaxoSmithKline, Turkey; ViiV Healthcare, Lithuania; ViiV Healthcare, Norway; ViiV Healthcare UK Limited, IcelandGlaxoSmithKline, Chile; GlaxoSmithKline, Finland; GlaxoSmithKline, Sweden; GlaxoWellcome, Georgia; ViiV, Estonia; ViiV Healthcare, Australia; ViiV Healthcare, Belgium; ViiV Healthcare, Czech Republic; ViiV Healthcare, Ireland; ViiV Healthcare, Japan; ViiV Healthcare, Netherlands; ViiV Healthcare, United States; ViiV Healthcare UK, United Kingdom; ViiV Healthcare ULC, Canada; ViiV Healthcare, Portugal; Wellcome Limited, Bosnia & HerzegowinaAbacus, Austria; Eurim-Pharm, Austria; Haemato Pharm, Austria; ViiV Healthcare, Austria; ViiV Healthcare, Luxembourg; ViiV Healthcare, OmanGlaxoSmithKline, Chile; GlaxoSmithKline, Finland; GlaxoSmithKline, Sweden; GlaxoSmithKline Brasil, Brazil; GlaxoWellcome, Georgia; GSK, Slovakia; ViiV, Estonia; ViiV Healthcare, Australia; ViiV Healthcare, Belgium; ViiV Healthcare, Czech Republic; ViiV Healthcare, France; ViiV Healthcare, Greece; ViiV Healthcare, Ireland; ViiV Healthcare, Israel; ViiV Healthcare, Japan; ViiV Healthcare, Luxembourg; ViiV Healthcare, Latvia; ViiV Healthcare, Netherlands; ViiV Healthcare, Romania; ViiV Healthcare, United States; Viiv Healthcare S.L., Spain; ViiV Healthcare UK, United Kingdom; ViiV Healthcare ULC, Canada; Wellcome Limited, Bosnia & HerzegowinaViiV Healthcare, Austria; ViiV Healthcare, SwitzerlandWe comply with the HONcode standard for trustworthy health information -