© 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.Domperidone is to be given only by or under the immediate supervision of your doctor.Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. Description: Domperidone is a peripheral dopamine-receptor blocker.It increases oesophageal peristalsis, lower oesophageal sphincter pressure, gastric motility and peristalsis, and enhances gastroduodenal coordination, thereby facilitating gastric emptying and decreasing small bowel transit time. For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease. Drug-Drug:Ketoconazoleqblood levels and the risk of cardiovascular toxicity and is contraindicated; other azole antifungals , macrolide anti-infectives and proteaseinhibitors may have similar effects. Domperidone is to be given only by or … All rights reserved. It is used to treat slowed movement in the gastrointestinal tract associated with diabetes and gastritis (inflammation of the stomach lining). Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. It may be taken by mouth or rectally, and is available as a tablet, orally disintegrating tablets, suspension, and suppositories. Domperidone passes into breast milk. Due to the potential risks to a nursing infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding (see also Uses section). Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone may be useful in diabetic and idiopathic However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate (equate) well with relief of symptoms.Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease; it blocks peripheral D2 receptors but does not cross the To induce lactation, domperidone is used at a dosage of 10 to 20 mg 3 or 4 times per day by mouth.Domperidone has been found effective in the treatment of Domperidone use is associated with an increased risk of However, a 2015 Australian review concluded the following:A single 20 mg oral dose of domperidone has been found to increase mean serum prolactin levels (measured 90 minutes post-administration) in non-lactating women from 8.1 ng/mL to 110.9 ng/mL (a 13.7-fold increase).For comparison, normal prolactin levels in women are less than 20 ng/mL, prolactin levels peak at 100 to 300 ng/mL at It was reported in 2007 that domperidone is available in 58 countries, including In the United States, domperidone is not currently a legally marketed human drug and it is not approved for sale in the U.S. On 7 June 2004, FDA issued a public warning that distributing any domperidone-containing products is illegal.Domperidone is not generally approved for use in the United States. Handbook covers dosage, side effects, interactions, uses. There is an exception for use in people with treatment-refractory gastrointestinal symptoms under an FDA Clc1cc2c(cc1)N(C(=O)N2)C5CCN(CCCN4c3ccccc3NC4=O)CC5InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) A European review concluded that domperidone is not as effective in this population as previously thought and alternative treatments should be considered. Includes App for iPhone, iPad, and Android smartphone + tablet. Although not all of these side effects may occur, if they do occur they may need medical attention. Davis Drug Guide PDF. Dom-Domperidone: Domperidone belongs to the group of medications called dopamine antagonists. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Davis’s Drug Guide for Nurses App + Web from F.A. Domperidone, sold under the brand name Motilium among others, is a medication used as an antiemetic, gastric prokinetic agent, and galactagogue.