Monitor therapeutic effectiveness. First, we were not able to perform survival analysis because the HIRA data is claims-based in accordance with the Personal Information Protection Act in Korea. I think it is fair to say that the tamoxifen may not always be the sole culprit.
Using absolute BMD (g/cm(2)), the mean difference from baseline was significant between the two groups both at spine (p=0.002) and femur (p=0.001), but not with the Z-score. The most common causes of bone loss in women are menopause and aging. An objective response may require 4–10 wk of therapy, longer if there is bone metastasis. Learn more about tamoxifen in pill form. 2004 Aug;17(8):1115-9. doi: 10.1515/jpem.2004.17.8.1115.Int J Adolesc Med Health. The incidence rate of osteoporosis in breast cancer survivors was 23.59 per 1000 person-years (95% CI, 23.00–24.20). In addition to its efficacy, it has also been perceived as having a beneficial effect on bone health. Reassure patient that this discomfort frequently signals a good tumor response. Chemotherapy and AI were significantly related to the risk of osteoporosis and osteoporotic fracture in patients between the ages of 40 and 49 years.The results of this study differ from those of previous studies. Tamoxifen is a selective estrogen receptor modulator that has been used in the treatment of pubertal gynecomastia. This site needs JavaScript to work properly. This can be explained by their perimenopausal status and long-term treatment with adjuvant tamoxifen. In this review, the majority of published studies demonstrated a protective effect of tamoxifen therapy on spinal BMD in postmenopausal patients with early stage breast cancer . BMD was measured with dual-energy X-ray absorptiometry. Side effects in women. Written informed consent from the participants' legal guardian/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements.JLe and HA: planned, wrote and revised the article. Approximately 27,000 breast cancer patients younger than 50 years were enrolled, comprising 150,798 person-years. We conclude that when pubertal bone development is concerned, tamoxifen is safe for the treatment of pubertal gynecomastia as neither bone mineralization nor growth potential was affected. Tamoxifen has partial estrogen agonist properties, which have a protective effect on bone mineral density and the cardiovascular system. Please enable it to take advantage of the complete set of features! Bone age and height was evaluated before treatment and again one year later. Name must be less than 100 characters Sheridan PubFactory Although it has not been approved for this indication, studies have shown it to be both successful and safe. Osteoporotic fracture incidence was assessed as 2.40 per 1000 person-years (95% CI, 2.23–2.60), with 647 events occurring in 269,075 person-years (Factors associated with the incidence of osteoporosis and osteoporotic fracture showed different patterns according to age subgroups (There were only 9 cases of osteoporotic fracture in 7,121 patients younger than 40 years, and OFS was not associated with an increased risk of osteoporotic fracture in these patients (In the total population, tamoxifen was significantly associated with a decreased risk of osteoporosis and osteoporotic fracture (The results of this large retrospective study show that the use of adjuvant tamoxifen does not increase the risk of osteoporosis and osteoporotic fracture in younger breast cancer survivors. Z-score and absolute BMD (g/cm(2)) was determined at baseline and 2 months after completing tamoxifen treatment. Second, after the practice-changing report from the Suppression of Ovarian Function Trial in 2015, adjuvant ovarian suppression in premenopausal breast cancer patients who remain premenopausal after chemotherapy, especially young patients, is recommended (In conclusion, tamoxifen is not associated with an increased risk of osteoporosis and osteoporotic fracture in premenopausal breast cancer patients. In the hip, the protection varies depending on the site. The current study, in accordance with other reports (Multiple factors are related to the incidence of osteoporosis. This cannot be said for aromatase inhibitors, and it is this depletive action on estrogen levels that is thought to have an adverse effect on cardiac and bone health. The aim of this study was to assess the effects of tamoxifen on bone mineral density (BMD) and skeletal maturation when used for pubertal gynecomastia. 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