Dermal carcinogenicity studies were not conducted. This summary is not meant to take the place of your doctor's advice. In another aspect, the composition is topically administered every two hours during waking hours. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. ZOVIRAX Cream was well tolerated in studies in patients with cold sores. The formulation was considered pleasant.Briefly, confluent Vero cell monolayers were infected with HSV type 1 or HSV type 2 at a multiplicity of infection of 10 and the resultant virus was used to infect primary Adult Human Dermal Microvascular Endothelial Cells for 1 hour and then the supernatant was replaced with fresh culture media and then incubated overnight in the presence of various concentrations of acyclovir, 2-deoxy-D-glucose or an equimolar combination of the two compounds. The effect of ZOVIRAX Cream has not been established in immunocompromised patients. Patient surveys were collected. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. Particularly, FIG. Surveyed patients ranged in age from 14 to 65 years old, with an average age of 42 years old. The optional oils and/or waxy compounds can constitute from 0.5% to 99.9% of the total weight of the composition. Outbreaks can be triggered by any one of several factors including stress, sunlight, fatigue, fever, illness, poor diet, food allergy, and hormonal changes. Current prescription topical treatments for herpes labialis include Zovirax® cream (5% acyclovir, GlaxoSmithKline/Biovail Pharmaceuticals, Inc.) which is FDA approved for the treatment of recurrent herpes labialis (cold sores) in adults and adolescents (12 years of age and older). By comparison, almost all HSV-2 is encountered after childhood, when people become sexually active.HSVs tend to infect cells of ectodermal origin. The flavor is optionally present from about 0.1% to about 5% by weight of the topical antiviral composition.In a further embodiment, the topical antiviral composition can optionally further comprise one or more colorants and/or opacifiers in order to blend with the skin tone of the patient, so long as the colorant or opacifier does not interfere with the antiviral action of the formulation. Hypoxanthines are compounds containing the purine derivative 1H-purin-6(9H)-one. TK-negative mutants may cause severe disease in infants and immunocompromised adults. In addition, very little to no scabbing occurred.A 23 year old female diagnosed with HSV-2 typically experienced about one recurrent outbreak per year with prodrome symptoms of tingling, soreness, and tenderness around the leg. In one aspect, the method of treating involves topical application of the composition in a form selected from a lip-balm, stick, cream or ointment. Suitable pharmaceutically-acceptable base addition salts of compounds of the present invention include metallic salts made from aluminum, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N′-dibenzylethyleneldiamine, choline, chloroprocaine, diethanolamine, ethylenediamine, meglumine (N-methylglucamine) and procain. Generally, if treatment was started early at prodrome, no visual outbreak would occur. Therapy should be initiated as early as possible following onset of signs and symptoms (i.e., during the prodrome or when lesions appear). Unfortunately, topical acyclovir therapy lacks efficacy as compared to oral or parenteral administrations. For example, in reference to the treatment of a latent herpes viral infection using the compositions of the present invention, a therapeutically effective amount refers to that amount of an antiviral compound which has the effect of (1) reducing the pain, tingling, burning or itching of the outbreak, (2) reducing the duration of the outbreak, (3) reducing the recurrence of outbreaks, and/or, (4) relieving to some extent (or, preferably, eliminating) one or more other symptoms associated with the outbreak such as, for example, ulceration, crusting, weeping and scabbing.The term “subject”, or “patient”, refers to an animal, for example a mammal, who is the object of treatment. Invest. In another specific aspect, the molar ratio of acyclovir to 2-deoxy-D-glucose is about 1:1.In a specific embodiment, the antiviral compound is acyclovir. The '555 patent discloses a topical pharmaceutical formulation for use in treating virus infections of the skin or mucosa and containing 9-(2-hydroxyethoxymethyl) guanine, or a salt or ester thereof, which comprises a dispersed oil phase and a continuous aqueous phase containing therein water, at least 30 wt % of a polyhydric alcohol and solublized acyclovir.Sintov et al., U.S. Pat. The subject, or patient, may be either male or female.The term “about” when used to refer to a therapeutically effective amount of an antiviral compound, or another compound, includes the specified amount ±10%.HSV-1 and 2 are virtually identical, sharing approximately 50% of their DNA and having over 80% of common antigens. 5536-17-4), Vidaribine monohydrate (9-beta-D-Arabinofuranosyl-9H-purine-6-amine monohydrate; CAS No. In another aspect, the flavoring is spearmint oil. H2031G or H2031G4) HSV-2 ELISA Test system can be used to test for the presence of HSV-2 IgG. Denavir® is applied every two hours during the day for four days.Zovirax® ointment (5% acyclovir, GlaxoSmithKline/Biovail Pharmaceuticals, Inc.) is approved for topical administration and is indicated in the management of initial genital herpes and in limited non-life-threatening mucocutaneous Herpes simplex virus infections in immunocompromised patients.