What they can't seem to show is effective E increase because of my current endocrine levels being vastly different from post menopausal women. Results show that EV can indeed be taken sublingually. The problem is that in liquids, the hemihydrate is easily dissolved like salt, leaving behind pure estradiol which is quickly absorbed. With valerate, the compound (estradiol in this case) is bound to a carbonyl to create an ester of estradiol. Sublingual is generally considered better. Estradiol hemihydrate dissolves faster and is … As i understand, Estradiol Hemihydrate has an efectivity rate of 1:1 getting to E2, so dosing is just 30% lower than EV. But if you do sublingual you need to get estradiol hemihydrate, not estradiol valerate. I hope this helped.Yes, that helps a lot, thank you. Estradiol Hemihydrate vs Estradiol Valerate This is a question not asking maybe which is better, but a comparisson of treatments. but then we get to valerates.With valerate, the compound (estradiol in this case) is bound to a Valerate is much more plausible for injections where the purpose is to slowly absorb over time so you're not injecting every day. Dr. Estradiol Hemihydrate is the hemihydrate form of estradiol, the most potent, naturally produced estrogen. Be excellent to each other.Looks like you're using new Reddit on an old browser. Group B : 40 women are give sildenafil citrate 25mg vaginally every 6 hours (a half of 50 mg tablet is crushed and dissolved in 2cc of distilled water and injected in to vagina) starting from day 2-14 of the cycle, in addition to oral 2mg of estradiol valerat 6-8 hourly from the day 2-14 of the menstrual cycle . Estradiol hemihydrate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. He's overwhelmed, and you guys send him 50-100 a day. Press question mark to learn the rest of the keyboard shortcuts This is a question not asking maybe which is better, but a comparisson of treatments.As i understand, Estradiol Hemihydrate has an efectivity rate of 1:1 getting to E2, so dosing is just 30% lower than EV.Dosing depends on sensivity to estradiol just like EV?I don't know, I have never used it, we don't have it here in the USA.New comments cannot be posted and votes cannot be castDr. Can anyone give me a good rundown on the real differences between valerate and hemihydrate estradiol, preferably with some good source material for more detailed information? but then we get to valerates. I'm trying to educate myself and decide if I want to stick with hemihydrate sublingual or switch to valerate injections. I had heard that valerate So I've been left a bit confused. Any idea on that, valerate having to go through first-pass metabolism to become "active"?New comments cannot be posted and votes cannot be castPress J to jump to the feed. It holds the compound basically. Hemihydrate is good for oral administration because it is super readily and easily absorbed and is ideal if you are OK with taking it daily.I think I may have strayed from your intended question... Is there any difference? Press question mark to learn the rest of the keyboard shortcuts Compare Estrace vs Estradiol head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. These data were compared with other estimates of estrogenic potency from the literature. The following sequence of equipotency was calculated: ethinyl estradiol = 100 x conjugated estrogens = 450 x estrone sulphate = 500 x estradiol-17 beta = 650 x estradiol valerate. The site may not work properly if you don't If you do not update your browser, we suggest you visit Press J to jump to the feed. see if my estradiol levels would spike tremendously with Estradiol Valerate, like Estradiol Hemihydrate has shown to do when taken sublingually. Does anyone have any strong evidence for one being better or worse than the other?A hemihydrate is basically a way to bind other compounds into a crystalline salt without any real chemistry. William Powers - Family Physician, LGBT care, Transgender Specific Care Powers can't respond to PM's anymore on literally any platform. I can't find any hemihydrate injectables, for example -- are they out there and just not on inhouse or allday? Estrace rated 7.4/10 vs Estradiol rated 6.3/10 in … If it were to be injected in a gritty, beach-water like oil, its effects would be similar to a slow release sublingual administration, which is totally plausible other than having to inject probably once every couple days. Or is there a reason valerate is used for injections and not hemihydrate? Many medications use it in order to "create" the substance inside the pill, otherwise the medication would be very tiny (1-2mg in this case) and also impossible to handle as a pill. But several friends have switched to injections recently and they have all raved that their results were significantly improved on the injections as compared to the pills.