Eur Rev Med Pharmacol Sci 19: 1291-1296.Mamaghani A, Maham M, Dalir-Naghadeh B (2013) Effects of Ginger Extract on Smooth Muscle Activity of Sheep Reticulum and Rumen. in China, at which time the proposed uses included stomach upset, diarrhea, nausea, cholera, bleeding, rheumatic disease, and toothache [1]. Previous Post. These data, supported by animal model data and human studies demonstrating an augmentation of gastric motility, indicate that ginger may be a potential alternative or adjunct treatment for gastroparesis.Ginger has been used for thousands of years for both dietary and medicinal purposes. #LWWGP. Interestingly, the mechanism of action was found to be somewhat different between the animal models, with rabbits and rats demonstrating muscarinic receptor involvement and guinea-pigs showing a separate and unknown mechanism. A study of 120 laparoscopic gynecologic surgery patients showed equivalence between ginger and metoclopramide versus placebo in terms of PONV and antiemetic requirements [20]. Ultrasound was used to measure antral area, fundal area/diameter, and antral contraction frequency; gastric half-emptying time was calculated using the change in antral area seen on ultrasound. My favorite: my recipe for Gingerbread Cookies . As the posts started to pile up it became apparent that some sort of Recipe Index was needed. Summary. Proposed causes for these symptoms include impaired proximal stomach relaxation in response to meals, increased visceral sensitivity to distension, gastric motility disorders, and alterations in central nervous system function. That’s one of my favorite things about ginger as a nausea remedy — there are so many ways to utilize it and at least one is bound to be well-tolerated. Four separate randomized controlled trials, with a total of over 700 patients studied, have shown benefit of ginger for patients undergoing chemotherapyin both adults and children [15-18]. Patients were evaluated for 21 days for end-points including the amount of feeding tolerated within 48 hours, total amount of feeding tolerated, nosocomial pneumonia (attributed primarily to aspiration), number of ICU-free days, number of ventilator-free days, and overall mortality. Vet Res Forum 4: 91-97.Micklefield GH, Redeker Y, Meister V, Jung O, Greving I (1999) Effects of Ginger on Gastroduodenal Motility. The largest of the studies included greater than 500 adult patients from 23 private oncology groups in New York in their final analysis. Educating, inspiring, and empowering others to live WELL with gastroparesis.Take a peek in my fridge, purse or pantry, and you’ll find some form of ginger in each one. Crystallized ginger works wonders for me, too, and I look forward to trying the syrup.If you really have an itch for something crunchy (like a cookie), the Triple Ginger Snaps at Trader Joe’s are delicious and you can actually see the chewy chunks of ginger right in them! Three dosages of ginger (0.5g, 1.0 g, and 1.5 g orally) were compared to placebo. Given these varying mechanisms, treatment for this condition can be difficult. Although overlapping, there appear to be two syndromes of dyspepsia: postprandial distress syndrome and epigastric pain syndrome [22]. An alternative treatment for this patient population, especially one with minimal side effects and improved tolerance, would be of significant clinical benefit. A clear benefit in the management of nausea and vomiting, both during pregnancy and associated with the administration of cancer chemotherapy, has been demonstrated. I haven’t tried that one. I looked it up and it has aluminum in it. What do u think about taking the Carafate. Interesting data in humans and animal models suggest a possible role in the management of patients with functional dyspepsia or gastroparesis. If all else fails there is a "Search" feature at the top right of the page. Specific benefit was noted for nausea, epigastric fullness, epigastric pain, and bloating. The Ginger People product I listed is also very good, but a bit stringier.I’m so glad to hear that you don’t have to take as much Zofran anymore! Ex vivo animal preparations used as bioassays were exposed to gingerols and shogoal, active ingredients from ginger, with results suggesting mild antagonistic effects on the M3 and 5-HT3 receptors (possibly involved in alleviating nausea) but no effect on 5-HT4 receptors involved in gastroduodenal motility [26].Hu et al. St. Louis, MO: Elsevier/Saunders; 2012: 1147-1153.Giacosa A, Morazzoni P, Bombardelli E, Riva A, Bianchi Porro G (2015) Can Nausea and Vomiting be Treated with Ginger Extract? 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