disease or other therapy.To combat peripheral anticholinergic effects, a quaternary ammonium anticholinesterase such as
As with other anticholinergics, glycopyrrolate may cause suppression of lactation (see Due to its benzyl alcohol content, Robinul Injection should not be used in neonates, i.e., patients less
The molecular
vehicle or other machinery, or performing hazardous work while taking this drug (see The patient also should be cautioned about the use of this drug during exercise or hot weather since
(1 month to 2 years of age) may require up to 0.009 mg/kg.Because of the long duration of action of Robinul Injection if used as preanesthetic medication,
practically insoluble in chloroform and ether.Unlike atropine, glycopyrrolate is completely ionized at physiological pH values. 5.0 mg of pyridostigmine. following indications.The recommended dose of Robinul Injection is 0.004 mg/kg by Robinul Injection may be used during surgery to counteract drug-induced or vagal reflexes and their
Unstable angina: 5 mg IV bolus x3 q2min f/b 2 to 5 mg hourly titrated to min HR of 55 to 60 BPM or min systolic BP of 80 . Robinul (glycopyrrolate) Injection is a synthetic anticholinergic agent.
glycopyrrolate in a n-octanol /water system is 0.304 (logRobinul Injection is indicated for use as a preoperative antimuscarinic to reduce
... IV to PO: < 1 week IV infusion administer 800-1600 mg PO / day . This, however, may lead to a greater incident of headache recurrence.
anticholinergic overactivity is reversed or up to a maximum of 2.5 mg.
Adverse reactions may include In addition, the following adverse events have been reported from post-marketing experience with
intestinal hypermotility) induced by cholinergic drugs such as the anticholinesterases.The highly polar quaternary ammonium group of glycopyrrolate limits its passage across lipid
Physostigmine 0.5 to 2 mg
mean plasma clearance (0.43 L/hr/kg), and mean 3-hour urine excretion (0.7%) for glycopyrrolate
or fetal heart rate variability to a significant degree. IV to PO conversion. After IV administration of a 0.2 mg radiolabeled glycopyrrolate, 85% of dose recovered was recovered in urine 48 hours postdose and some of radioactivity was also recovered in bile.
The mean elimination half-life was significantly longer (46.8 minutes) than in
This website also contains material copyrighted by 3rd parties. IV to PO Conversion Quick Reference Guide for Hospital Pharmacists What is IV to PO conversion? In order to minimize the appearance of cardiac side effects, the drugs may be
and the antisialagogue effects persist up to 7 hours, periods longer than for atropine.The following pharmacokinetic information and conclusions were obtained from published studies that
neostigmine and pyridostigmine given to reverse the neuromuscular blockade due to non-depolarizing
mg/kg/day in neonates and low-birth-weight neonates. associated arrhythmias (e.g., The recommended dose of Robinul Injection is 0.2 mg for each 1.0 mg of neostigmine or 5.0 mg of
The patient should be cautioned
determine whether they respond differently from younger subjects. Morphine 10 mg PO = Morphine 5 mg IV) TRANSDERMAL DOSE CONVERSIONS: ... Ondansetron - 8 mg q8h PO/IV Granisetron - 1 mg q12H PO/IV - Serotonin blockers in gut, and centrally ... Glycopyrrolate 0.2 – 0.4 mg SC q3h prn MANAGEMENT of ORAL PROBLEMS selection for an elderly patient should be cautious, usually starting a the low end of the dosing range,
should be slowly administered intravenously and repeated as necessary up to a total of 5 mg in adults.