They are a type of polyphenols that act as powerful antioxidants and can help to eliminate free radicals and other harmful toxins that contribute to disease. The total leukocyte count is a good, objective guide for regulating dosage. Women of childbearing potential should be advised to avoid becoming pregnant.Cyclophosphamide interferes with oogenesis and spermatogenesis. help if any of these side effects or any other side effects bother you or do not go away: See Second malignancies have developed in some patients treated with cyclophosphamide used alone or in association with other antineoplastic drugs and/or modalities. a. If you need to store Cytoxan (cyclophosphamide injection) at home, talk with your doctor, nurse, or pharmacist about how to store it. These adverse effects appear to depend on the dose of cyclophosphamide and the duration of therapy. The health and safety policy, as it relates to areas, activities and persons under their control is understood, implemented, maintained and monitored. If generic versions of this product have been approved by the FDA, there may be Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase system. These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells. The following malignancies are often susceptible to Cytoxan treatment:Cytoxan is useful in carefully selected cases of biopsy proven “minimal change” nephrotic syndrome in children but should not be used as primary therapy. Anorexia and, less frequently, abdominal discomfort or pain and diarrhea may occur. Ectrodactylia was found in two of the three cases. Learn more about the symptoms, complication, causes, types, diagnosis, treatment, lifestyle changes, and outlook for lupus. Please Diarrhea 4. Search engine giant Google is intensely focusing its efforts and heavily investing in the health-tech space. Irregular Periods 8. Second malignancies most frequently were detected in patients treated for primary myeloproliferative or lymphoproliferative malignancies or nonmalignant disease in which immune processes are believed to be involved pathologically.In some cases, the second malignancy developed several years after cyclophosphamide treatment had been discontinued. The Cytoxan brand name has been discontinued in the U.S. cyclophosphamide (cytoxan) cost Ignoring the one-off costs associated with the write downs, the company still saw its underlying profits fell by a third in the first half of the year, to $1.2bn from the combined profit of $1.8bn earned by the two companies a year earlier. Read all information given to you. Pigmentation of the skin and changes in nails can occur. Decreased Appetite 3. Inactive ingredients in Cytoxan Tablets are: acacia, FD&C Blue No. A Reduction In The Body's Resistance To Infection 2. Solutions of Cytoxan may be injected intravenously, intramuscularly, intraperitoneally, or intrapleurally if constituted by adding 0.9% sterile sodium chloride solution.Cytoxan may be prepared for parenteral use by infusion using any of the following methods:Cytoxan (prepared for either direct injection or infusion) is chemically and physically stable for 24 hours at room temperature or for six days in the refrigerator; it does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions.The osmolarities of solutions of Cytoxan constituted with water and 0.9% sterile sodium chloride solution are found in the following table:Isotonic 0.9% sterile sodium chloride solution has an osmolarity of 289 mOsm/L.Extemporaneous liquid preparations of Cytoxan for oral administration may be prepared by dissolving Cytoxan in Aromatic Elixir, N.F. Interstitial pulmonary fibrosis has been reported in patients receiving high doses of cyclophosphamide over a prolonged period.Anaphylactic reactions have been reported; death has also been reported in association with this event. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range and adjusting as necessary based on patient response (see Information on adverse reactions associated with the use of Cytoxan (cyclophosphamide) is arranged according to body system affected or type of reaction.