The FDA’s warning came as the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) told Pfizer to suspend all advertising containing claims that Zyvox had superior cure rates compared with vancomycin after one such ad appeared in the British Medical Journal. Edited by Longnecker DE, Tinker JH, Morgan GE.
This site uses cookies. You can be signed in via any or all of the methods shown below at the same time.The email address and/or password entered does not match our records, please check and try again. * University of Maryland Medical System and Baltimore Veterans Administration Hospital. J Clin Pharmacol 2001; 41:563–72Breslow MJ: Clinical implications of the stress response to surgery: Principles and Practice of Anesthesiology, 2nd edition. It is the only antibiotic with a United States Food and Drug Administration (US FDA) approval for treatment of VRE infections, including cases with bacteremia.Daptomycin is a lipopeptide antibiotic with potent In several meta-analyses published prior to 2015, the results indicate that linezolid may have improved survival as compared with daptomycin for treatment of VRE-B.We performed a single-center, retrospective cohort study of adult inpatients with VRE-B treated with either linezolid or daptomycin between January 2012 to August 2016 at an academic medical center in New Brunswick, New Jersey, USA. After a trial of several antibiotics, he was placed on linezolid for treatment of resistant, gram-positive organisms. Daptomycin and linezolid are primary treatment options although definitive clinical data to assess comparative therapeutic effectiveness are lacking. J Clin Psychopharmacol 1993; 13:312–20Sporer A: The serotonin syndrome: Implicated drugs, pathophysiology and management. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( the site you are agreeing to our use of cookies. Research Triangle Park, NC: GlaxoSmithKline, 2001Graber MA, Hoehns TB, Perry PJ: Sertraline-phenelzine drug interaction: A serotonin syndrome reaction. Other drugs Pfizer has settled civil charges related to Bextra include schizophrenia drug Geodon, antibiotic Zyvox and anti-epilepsy drug Lyrica. This helps to limit the influence of factors on outcome measures difficult to evaluate retrospectively, such as proper source control for all patients. Neurology 1995; 45:219–23Wigen CL, Goetz MB: Serotonin syndrome and linezolid. Vancomycin-resistant enterococcal bacteremia (VRE-B) is a common nosocomial infection associated with significant morbidity and mortality. Patients were identified by consecutive sampling through the microbiology laboratory database. Covariates included age, sex, weight, hospital onset of bacteremia (at least 48 hours after hospital admission), intensive care unit admission day 1 of index blood culture (ICU day 1), presumed source of infection, presence of central line, hematologic malignancy, neutropenia (absolute neutrophil count <500 cell/mmThe primary outcome measure was clinical failure, defined as a composite of 14-day in-hospital mortality, microbiologic failure (positive blood cultures for ⩾4 days following index blood culture with at least 72 h of effective antibiotic therapy or died with persistently positive blood cultures), or VRE-B relapse (positive blood culture with VRE within 30 days of index blood culture after documented clearance). His intraoperative course was notable for several episodes of severe hypertension (as high as 260/145 mmHg), despite an otherwise stable anesthetic. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Our Limitations to our study should be considered to appropriately interpret these findings. Linezolid is a valuable drug that is finding increased use in the hospitalized surgical patient for the treatment of infections resulting from resistant, gram-positive organisms. Daptomycin and linezolid are primary treatment options although definitive clinical data to assess comparative therapeutic effectiveness are lacking. There was a significantly higher rate of clinical failure in the daptomycin group as compared with the linezolid-treated patients (74.2% We sought to assess the clinical and microbiologic outcomes of patients with VRE-B treated with either daptomycin or linezolid. J Antimicrobial Chemother 2003; 51(Suppl 2):II45–53Wellbutrin [package insert]. Second, mortality and relapse of VRE-B were only assessed through inpatient hospitalization at our institution. 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