2013, 10.1093/infdis/jit275.Zhu H, Wang HP, Jiang Y, Hou SP, Liu YJ, Liu QZ: Mutations in 23S rRNA and ribosomal protein L4 account for resistance in chlamydia trachomatis strains selected in vitro by macrolide passage. The aim of this cohort study is to estimate the proportion of women … All authors read and approved the final manuscript.Below are the links to the authors’ original submitted files for images.This article is published under license to BioMed Central Ltd. Sex Transm Infect. Organize with favorites and folders, choose to follow along via email, and quickly find unread posts. This will be broken down into smaller payments, $25 at their first follow up visit, $10 for their day 14 specimen, $10 for their day 21 specimen, $25 for their day 28 specimen and then $30 upon completion of the study (day 56 specimen or earlier if repeat positive). 10.1128/JCM.00883-11.Christerson L, Herrmann B: Guidelines for high-resolution genotyping of chlamydia trachomatis using multilocus sequence analysis. 1990, 162: 1309-1315. 2013, London: RCGP/BASHH, 2Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines. J Infect Dis. Multiple strategies to support partner treatment will be explored. ACTS has been funded by a National Health and Medical Research Council project grant (APP1023239).This study has been externally funded by the Australian Government funding body, the National Health and Medical Research Council (NHMRC - project grant number APP1023239).Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie St, Carlton, 3053, Victoria, AustraliaMurdoch Children’s Research Institute, Parkville, 3052, Victoria, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, 4057, Queensland, AustraliaMelbourne Sexual Health Centre, 580 Swanston Street, Carlton, 3053, Victoria, AustraliaSydney Sexual Health Centre, Sydney Hospital, Macquarie Street, Sydney, 2001, New South Wales, AustraliaDepartment of Microbiology and Infectious Diseases, the Royal Women’s Hospital, Parkville, 3052, Victorian, AustraliaDepartment of Obstetrics and Gynaecology, University of Melbourne, Carlton, 3053, Victoria, Australiathe Australian Chlamydia Treatment Study (ACTS) investigators, AustraliaYou can also search for this author in 10.1097/OLQ.0b013e3181a2a933.Handsfield HH: Questioning azithromycin for chlamydial infection. 10.1097/00007435-200209000-00001.Dean D, Suchland RJ, Stamm WE: Evidence for long-term cervical persistence of chlamydia trachomatis by omp1 genotyping. 2006, 8: 16-26. 10.1111/j.1439-0272.2009.01019.x.Huston W, Theodoropoulos C, Mathews S, Timms P: Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA. 2004, 42: 239-241. Future Microbiol. Real-time PCR directed at amplification of a region of the Y chromosome targeting SRY (sex determining region Y) will be conducted [Endocervical specimens collected by speculum examination will be used for chlamydia culture. The study endpoint will be measured by a test of cure PCR conducted after 28, 42 or 56 days follow up according to Figure Participants will be asked to return to the clinic for follow up testing at day 7 so that the research nurse can collect further specimens. J Clin Microbiol. 10.1128/JCM.42.1.239-241.2004.Dean D, Bruno W, Wan R, Gomes J, Devignot S, Mehari T, Vries H, Morre S, MYers G, Read T, Spratt B: Predicting phenotype and emerging strains among chlamydia trachomatis infections. If the risk of treatment failure is observed to be 3% (as reported by the earlier meta-analysis [The population risk of treatment failure will be estimated as the observed proportion of women in the sample with treatment failure, with 95% CI calculated assuming an underlying binomial distribution. Sex Transm Dis. 2012, 7: e37778-10.1371/journal.pone.0037778.Gomes JP, Borrego MJ, Atik B, Santo I, Azevedo J, Brito de Sa A, Nogueira P, Dean D: Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis. 2000, 18: 909-916.Hocking JS, Low N, Guy R, et al: 12 PRT 09010: Australian chlamydia control effectiveness pilot (ACCEPt): a cluster randomised controlled trial of chlamydia testing in general practice (ACTRN1260000297022). J Clin Microbiol. 2008, 8: 190-10.1186/1471-2180-8-190.Nirogi RVS, Kandikere VN, Shukla M, Mudigonda K, Maurya S, Boosi R, Yerramilli A: Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of azithromycin in human plasma. 10.1136/sextrans-2011-050385.Sandoz KM, Rockey DD: Antibiotic resistance in chlamydiae. Among women who tested positive in an Australian cohort of 1116 young women who were treated at recruitment, 18% tested positive again at 3 months (95% CI: 8%, 34%) [Repeat infections are generally considered to be re-infections through exposure to an infected partner. PLoS One. All laboratory assay results will be forwarded to the study centre and entered into the study database.At the time of recruitment, the research nurse will explain the importance of treating sexual partners and avoiding sexual contact for 7 days.