This medicine may be taken alone or used along with medicines that are applied to the skin for fungus infections. Patients should be cautioned to avoid consumption of alcoholic beverages, and medicines containing alcohol, while undergoing griseofulvin therapy.In patients undergoing long term griseofulvin therapy, i.e for tinea unguium, consideration should be given to periodic monitoring of blood chemistry, particularly for patients with pre-existing blood disorders, since griseofulvin may cause blood disorders, see section 4.8.In common with any antibiotic, therapy with griseofulvin may result in the overgrowth of non-susceptible organisms, i.e bacteria or yeasts, or non-dermatophyte fungi, that are often cofactors in tinea infections, especially tinea pedis. NDC 0781-5514-01, in bottles of 100 tablets Concomitant use of appropriate topical agents is usually required, particularly in treatment of tinea pedis. To find out how griseofulvin oral tablet might interact with something else you’re taking, talk to your doctor or pharmacist.When certain drugs are used with griseofulvin, these other drugs may not work as well. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Our website services, content, and products are for informational purposes only. It is prescribed in particular for an infection called scalp ringworm (also called tinea capitis). There is selective deposition of griseofulvin in newly formed keratin of hair, skin, and nails, which gradually moves to the surface of these appendages.Griseofulvin undergoes metabolism to inactive metabolites, principally 6- desmethylgriseofulvin, or its glucuronide conjugate.The terminal plasma half life ranges from 9.5-21 hours, with considerable intersubject variability. Patients should therefore be cautioned not to drive or operate machines until they are sure they are not affected.The following frequencies are used for the description of the occurrence of undesirable effects:Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.Headache and gastric discomfort are the most common effects on starting treatment, but usually disappear as treatment is continued.Rare: leucopenia, neutropenia, anaemia-these usually resolve on therapy cessationUncommon: impaired co-ordination, peripheral neuropathy, confusion, dizziness, drowsiness, insomnia, irritability.Common: diarrhoea, vomiting, nausea, gastric discomfortUncommon: toxic epidermal necrolysis, erethema multiforme, photosensitivity on exposure to intense natural or artifical sunlight.Rare: precipitation of Systemic Lupus Eryhthematosus, bullous reactions including Lyell's syndrome, urticarial reactions, skin rashes.Very rare: alteration in liver function tests, with elevation to more than three times upper normal limit, intrahepatic cholecstasis, hepatitis.The likely symptoms of any overdose would be nausea, nomiting, headache, numbness and tingling, confusion, and vertigo. Date of first authorisation/renewal of the authorisation This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription. The table below contains some of the most common ones associated with griseofulvin. Easy-to-read patient leaflet for Griseofulvin Microsize Tablets. The remainder of the dose, principally as metabolites, is excreted in bile and faeces.Griseofulvin can induce aneuploidy and meiotic delay in mouse oocytes following oral administration of high doses, i.e. Patient does not provide medical advice, diagnosis or treatment.Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Patient is a UK registered trade mark.By using this site you agree to our use of cookies. If you can’t, be sure to wear protective clothing and sunscreen.Some insurance companies require a prior authorization for this drug. Griseofulvin binds to tubulin, affecting microtubule function and inhibiting mitosis. It comes with risks if you don’t take it as prescribed.If you think you’ve taken too much of this drug, call your doctor or local poison control center. It should not be used in people younger than 2 years.If you take a higher dosage of this drug or use it for a long time, you may have a higher risk of more severe side effects. For details see our Our clinical information is certified to meet NHS England's Information Standard.Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals.© Patient Platform Limited. The usual adult dose is 500 mg to 1000 mg daily. This helps make sure you stay safe during your treatment. Take the container with you, even if it is empty.This medicine is for you. 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