In the present study, in the context of a randomized, double-blind, placebo-controlled, 1-year discontinuation and maintenance study of 53 patients with panic disorder with agoraphobia who respond to imipramine, the authors examine the extent and the specificity of these five side effects of imipramine maintenance using data at pretreatment, at the end of 24 weeks of open imipramine treatment (or month 0 of randomization), and at months 2, 4, 6, 8, 10, and 12 of randomized treatment. Mavissakalian M(1), Perel J, Guo S. Author information: (1)Department of Psychiatry, Case Western Reserve University and Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. doi: 10.1097/00004714-199812001-00004.Bighelli I, Castellazzi M, Cipriani A, Girlanda F, Guaiana G, Koesters M, Turrini G, Furukawa TA, Barbui C.Cochrane Database Syst Rev. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. doi: 10.1002/14651858.CD010676.pub2.Curr Neuropharmacol. Wolters Kluwer If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Although sexual dysfunction and weight gain were not a significant burden in that study, they are important problems in long-term treatment with antidepressant drugs. doi: 10.1097/00004714-200204000-00008. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Along with its needed effects, a medicine may cause some unwanted effects. All rights reserved. 2000 Oct;20(5):547-55. doi: 10.1097/00004714-200010000-00010.Mavissakalian MR, Perel JM, Talbott-Green M, Sloan C.Biol Psychiatry. 1998 Dec;18(6 Suppl 2):12S-18S. Disabling and Potentially Irreversible Serious Adverse Reactions That May Occur Together: Inform patients that disabling and potentially irreversible serious adverse reactions, including tendinitis and tendon rupture, peripheral neuropathies, and central nervous system effects, have been associated with use of LEVAQUIN ® and may occur together in the same patient. Ann Clin Psychiatry. 2015;13(6):739-49. doi: 10.2174/1570159x13666150612230045.DeBoer LB, Powers MB, Utschig AC, Otto MW, Smits JA.Expert Rev Neurother. This site needs JavaScript to work properly. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 2003 Sep-Dec;15(3-4):171-80. doi: 10.1023/b:acli.0000008170.74985.b6.J Clin Psychopharmacol. These side effects may go away during treatment as your body adjusts to the medicine. The results are discussed in the context of previous studies of imipramine side effects in the management of depression and the available literature of sexual and weight side effects of antidepressant medications in the treatment of anxiety disorders. The authors report results of a double-blind study in which the effects of imipramine, phenelzine, and placebo on specifi … Wolters Kluwer Please enable it to take advantage of the complete set of features! There has been little systematic study of the types of sexual dysfunction produced by antidepressant medication or of the frequency with which this type of adverse effect occurs. 2012 Aug;12(8):1011-22. doi: 10.1586/ern.12.73. The data also revealed that weight gain is a significant and specific side effect of 1-year imipramine maintenance treatment; however, the likelihood of reporting sexual dysfunction decreased over time, with no difference between the placebo and imipramine maintenance conditions. You may report side effects to the FDA at 1-800-FDA-1088.Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Get emergency help immediately if any of the following symptoms of overdose occur:Some side effects may occur that usually do not need medical attention.