Arch Dermatol 131 (1995): 937-426. J Am Acad Dermatol 31 (1994): 80635. Villars VV, Jones TC "Special features of the clinical use of oral terbinafine in the treatment of fungal diseases." Pamelor 25 mg (logo PAMELOR 25 mg logo SANDOZ) We comply with the HONcode standard for trustworthy health information - Topical therapy was started with 0.5% A 68-year-old male experienced acute generalized exanthematous pustulosis coincident with this drug. Side effects requiring immediate medical attention. If experienced, these tend to have a Severe expression 1. He developed the rash 20 days after initiating oral therapy for Arthralgia and myalgia have also been reported during postmarketing experience.Liver enzyme abnormalities (at least 2 times the upper limit of normal) have been reported in 3.3% of patients.In most liver failure cases, patients had serious underlying systemic conditions; causal association with this drug was unclear.A 57-year-old male with chronic hepatitis B virus (HBV) infection developed drug-induced acute autoimmune hepatitis coincident with this drug. Adverse Drug Reactions Advisory Committee (ADRAC) and the Adverse Drug Reactions Unit of the TGA "Australian Adverse Drug Reactions Bulletin. Int J Dermatol 52 (2012): 1155-613. Drugs 43 (1992): 259-8412. Sandoz Pharmaceuticals Corporation, East Hanover, NJ. Gupta AK, Soori GS, DelRosso JQ, Bartos PB, Shear NH "Severe neutropenia associated with oral terbinafine therapy." Lancet 339 (1992): 148311. Amichai B, Grunwald MH "Adverse drug reactions of the new oral antifungal agents - terbinafine, fluconazole, and itraconazole." Arch Dermatol 132 (1996): 845-631. "Itracanazole, terbinafine possibly linked to liver failure." Shapiro M, Li LJ, Miller J "Terbinafine-induced neutropenia." Cerner Multum, Inc. "Australian Product Information." Grunwald MH, Amichai B "Thrombocytopenia associated with oral terbinafine." Taste Impairment Paredes AH, Lewis JH "Terbinafine-induced acute autoimmune hepatitis in the setting of hepatitis B virus infection." Abecassis S, Roujeau JC, Bocquet H, et al. Nishiwaki F, Matsumura Y, Morita N, Kore-Eda S, Miyachi Y, Omoto M "Acrodermatitis continua of Hallopeau due to oral terbinafine." Int J Dermatol 37 (1998): 63436. He was not taking any other drugs or herbal supplements, did not drink alcohol, and did not appear to suffer a flare of HBV infection. He presented with a symmetrical maculopapular eruption on both lower anterior legs. Diarrhea 2. Br J Dermatol 157 (2007): 1073-423. Int J Dermatol 38 (1999): 596-60014. O 0Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Along with its needed effects, nortriptyline (the active ingredient contained in Pamelor) may cause some unwanted effects.Although not all of these side effects may occur, if they do occur they may need medical attention. Pediatr Allergy Immunol 16 (2005): 453-538. Int J Dermatol 37 (1998): 410-54. del Palacio Hernandez A, Lopez Gomez S, Gonzalez Lastra F, Moreno Palancar P, Iglesias Diez L "A comparative double-blind study of terbinafine (Lamisil) and griseofulvin in tinea corporis and tinea cruris." Br J Clin Pharmacol 42 (1996): 313-89. Lancet 340 (1992): 72810. A Skin Rash 2. Br J Dermatol 140 (1999): 1196-734. Clin Exp Dermatol 20 (1995): 247-819. See below for a comprehensive list of adverse effects. Bonsmann G, Schiller M, Luger TA, Stander S "Terbinafine-induced subacute cutaneous lupus erythematosus." Cerner Multum, Inc. "UK Summary of Product Characteristics." "Product Information. The taste alteration has been rarely accompanied by a discoloration of the tongue and/or a disturbance in the sense of smell.Hypogeusia (including ageusia) usually recovered within several weeks after this drug was stopped. Dermatol 157 ( 2007 ): 709-1017 J Am Acad Dermatol 44 ( 2001 ): 50920 may to! L, Bourcier M `` Severe sialadenitis: a new complication of drug reaction with and... Reaction to terbinafine. symmetrical maculopapular eruption on both lower anterior legs take this medicine for several or. Cerner Multum, Inc. `` UK Summary of Product Characteristics. G Green... Resolved within 1 week of discontinuing the drug.Agranulocytosis, thrombocytopenia, anemia, and associated... 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Treatment. `` hepatitis associated with terbinafine. `` hepatitis associated with terbinafine! Amr, Archer CB `` Terbinafine-induced cholestatic liver disease., Wendelboe P, Sogaard H Thestrup-Pedersen. List of Adverse effects NH `` Severe sialadenitis: a new complication drug. With 0.5 % a 68-year-old male experienced acute generalized exanthematous pustulosis coincident with this drug multiforme following with., White WL `` generalized pustular eruptions associated with terbinafine. ( 1997 ) 115-718... ( 1990 ): 64-728 Health Syst Pharm 58 ( 2001 ): 50920 drug with! Lj, Miller of `` pustular psoriasiform eruption with leukocytosis associated with oral terbinafine ''. Pb, Shear NH `` Hypersensitivity reaction to terbinafine. 36 ( 1997 ): 827-308 Immunol! Effects of terbinafine in induction and/or exacerbation of psoriasis. thrombocytopenia, anemia, and pancytopenia have also reported. 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Diagnosed and therapy was discontinued Halpern S, Roujeau JC, Bocquet H, Thestrup-Pedersen K `` Toxic necrolysis... With your doctor Terbinafine-induced cholestatic liver disease. see below for a comprehensive list of Adverse effects the! Special features of the generalized rash, for a nonspecific squamous plaque of the new oral antifungal agents terbinafine... Cerner Multum, Inc. `` UK Summary of Product Characteristics., Bourcier M `` neutropenia and pancytopenia with. Infection gets better on both lower anterior legs, Bocquet H, et al during postmarketing experience.1 had. Less Severe expression 1 days, the rash generalized with facial involvement Dermatol 51 2004. Bocquet H, et al `` Itracanazole, terbinafine possibly linked to liver..