Both in U.S. clinical trials in mild-to-moderate heart failure that compared Coreg in daily doses up to 100 mg (n = 765) with placebo (n = 437), and in a multinational clinical trial in severe heart failure (COPERNICUS) that compared Coreg in daily doses up to 50 mg (n = 1,156) with placebo (n = 1,133), discontinuation rates for adverse experiences were similar in carvedilol and placebo subjects. Coreg should be discontinued over 1 to 2 weeks whenever possible. For individual adverse events this could only be distinguished for dizziness, which increased in frequency from 2% to 5% as total daily dose increased from 6.25 mg to 50 mg.The following adverse events not described above were reported as possibly or probably related to Coreg in worldwide open or controlled trials with Coreg in subjects with hypertension or heart failure.The following events were reported in less than or equal to 0.1% of subjects and are potentially important: complete AV block, bundle branch block, myocardial ischemia, cerebrovascular disorder, convulsions, migraine, neuralgia, paresis, anaphylactoid reaction, alopecia, exfoliative dermatitis, amnesia, GI hemorrhage, bronchospasm, pulmonary edema, decreased hearing, respiratory alkalosis, increased BUN, decreased HDL, pancytopenia, and atypical lymphocytes.Reversible elevations in serum transaminases (ALT or AST) have been observed during treatment with Coreg. Show this list to your doctor and pharmacist before you start a new medicine.Other side effects of Coreg include shortness of breath, weight gain, diarrhea, and fewer tears or dry eyes that become bothersome if you wear contact lenses.Call your doctor if you have any side effects that bother you or don’t go away.Call your doctor for medical advice about side effects. The dosing recommendations should be followed closely and the dose should be lowered if any evidence of bronchospasm is observed during up-titration.In general, β-blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia. However, this is the first study to observe that these symptoms persist beyond the first week. Abrupt withdrawal of β-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm.In patients with pheochromocytoma, an α-blocking agent should be initiated prior to the use of any β-blocking agent. The Australia‑New Zealand results were statistically borderline.In this double-blind trial, 3,029 subjects with NYHA class II-IV heart failure (left ventricular ejection fraction less than or equal to 35%) were randomized to receive either carvedilol (target dose: 25 mg twice daily) or immediate-release metoprolol tartrate (target dose: 50 mg twice daily). Do not give Coreg to other people, even if they have the same symptoms you have. Probably not. Infants were examined using a structured neurobehavioral assessment (Neonatal Intensive Care Unit Network Neurobehavioral Scale) at several time points during the first month of life: at days 2, 4, and 7 when levels of SSRIs in exposed infants are likely to be changing rapidly and at days 14 and 30.The researchers compared outcomes in the following groups of women:Group B: Depression during pregnancy, but no SSRI exposure (n=56)Group D: Exposure to SSRI and benzodiazepines (n=10)Infants in both the SSRI and SSRI plus benzodiazepine exposure groups had lower quality of movement than those in the no-exposure group and those in the depression group. Likewise, hydrochlorothiazide had no effect on the pharmacokinetics of carvedilol.In a pharmacokinetic trial conducted in 8 healthy male subjects, rifampin (600 mg daily for 12 days) decreased the AUC and CIn a trial of 12 healthy subjects, combined oral administration of carvedilol 25 mg once daily and torsemide 5 mg once daily for 5 days did not result in any significant differences in their pharmacokinetics compared with administration of the drugs alone.Carvedilol (12.5 mg twice daily) did not have an effect on the steady-state prothrombin time ratios and did not alter the pharmacokinetics of R(+)- and S(-)-warfarin following concomitant administration with warfarin in 9 healthy volunteers.In 2-year studies conducted in rats given carvedilol at doses up to 75 mg per kg per day (12 times the MRHD as mg per mCarvedilol was negative when tested in a battery of genotoxicity assays, including the Ames and the CHO/HGPRT assays for mutagenicity and the in vitro hamster micronucleus and in vivo human lymphocyte cell tests for clastogenicity.In a combined fertility/developmental/post-natal toxicity study, rats were given carvedilol (12, 60, 300 mg per kg per day) orally by gavage for 2 weeks before mating and through mating, gestation, and weaning for females and for 62 days prior to and through mating for males. 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