Do not take any herbal remedies that make you feel sleepy while taking melatonin. Are UK GP's limited to a specific prednisolone dosage in their prescribing rules? Use of the lowest effective dose will tend to minimise side-effects. Supplemental melatonin may decrease the effect of corticosteroid drugs if taken at the same time. Research has found that taking melatonin in low doses is the most effective way to promote sleep if you are experiencing restlessness or insomnia. The following side effects have been observed and reported during treatment with Prednisolone Pfizer at the following frequencies: Very common (≥1 / 10), common (≥1 / 100, <1/10) less common (≥1 / 1,000, <1/100), rare (≥1 / 10,000, <1/1000), very rare (<1/10,000), no known frequency (cannot be calculated from available data). Glucocorticoids increase blood sugar levels. The plasma half-life is normally 2 to 4 hours. After prolonged treatment, tapering of dose below 7.5 mg (regarded as “equivalent” to physiological levels of glucocorticoids) should be conducted particularly cautiously. If long-term treatment is required, the infant / child's growth and development should be closely monitored (see section 4.2). Prednisolone is highly bound to plasma proteins and has high affinity for the transcortin. Existing emotional instability and psychotic tendencies can also be exacerbated by corticosteroids (see section 4.8). Recommended doses of melatonin are from 0.5 mg up to 3 mg, which are adequate to promote sleep or treat jet lag. Using too much melatonin can disrupt your circadian rhythm. It is advised to avoid using together. Melatonin is shown to have strong antioxidant activity, as well as being a potent scavenger of free radicals. A "steroid withdrawal syndrome", apparently without associated with adrenal insufficiency, may also occur following abrupt withdrawal of glucocorticoids. Withdrawal of doses of up to 40mg daily of prednisolone, or equivalent that have been administered for less than 3 weeks is unlikely to lead to clinically relevant HPA-axis suppression, in the majority of patients. Since the secretion of mineral corticoids may be impaired, salts and / or mineral corticoids should be administered simultaneously. LDN + Melatonin helped me while on prednisone to get quality some rest. You can acquire common Prednisolone from a reliable online drug store within simply a couple of times, and you know this is visiting be excellent quality medicine you anticipated. I have been on 6mp since Jan. And never saw a difference, was on hydrocort and Apriso at the same time. Systemic corticosteroids should be used with caution in patients with heart failure or hypertension. Administration of live vaccines is contraindicated in patients receiving corticosteroids in immunosuppressive doses. The following information includes only the average doses of this medicine. Possibly, acute overdose may aggravate preexisting disease states such as ulcers, electrolyte disorders, infections and edema. Corticosteroids should be used with caution in patients with osteoporosis. It allows continued monitoring of the benefit/risk balance of the medicinal product. Maximum plasma concentration is achieved after 1 to 2 hours after oral administration. Of note, although controversy continues, studies have shown some promise in the use of melatonin as adjunctive therapy potentiating the anticonvulsant effect of phenobarbital, in the treatment of seizures in rats. Corticosteroids should be used with caution in patients with renal insufficiency. This information is intended for use by health professionalsWhite, 7mm, round, flat, tablet, with a score line on one side, imprinted with “A620” on one side and “5” on the other.The lowest effective dose should be used for the minimum period.Prednisolone should only be used when specifically indicated, at the lowest dose possible and for the shortest possible time.The initial dosage of Prednisolone may vary from 5mg to 60mg daily depending on the disorder being treated. Veteran Member. Divided daily dosage may be used. On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age.