age [see The estimated background risks of major birth defects and
In addition, decreased
of digoxin by 10% (30% in two subjects). predictions from a population PK model comparing I.V. more than 10 days have not been demonstrated. and further diluting the resulting solution to a final volume of 50 mL. ulcers and liver impairment, no dosage adjustment of the initial esomeprazole
AUC of one of its active metabolites, 3,4-dihydro-cilostazol, which has 4-7
68 times a daily human dose of 40 mg based on body surface area. to years after initiating treatment primarily in patients ranging from young
Rates of spontaneous and elective abortions, preterm
In patients with severe
compared to placebo in the risk of rebleeding within 72 hours in patients with
normally required for the recommended doses. (Administer within 6 hours if 5% Dextrose Injection is
wellcontrolled studies that supported the approval of NEXIUM I.V. Gastric carcinoids
For patients with mild
treatment at least 14 days before assessing CgA levels and consider repeating
ANA) may be positive and elevated serological test results may take longer to
plus 71.5 hours of continuous infusion). The majority of PPI-induced lupus erythematosus
of existing autoimmune disease. with 40 mg esomeprazole reduces the pharmacological activity of clopidogrel. observed in offspring of rats treated with oral doses of esomeprazole magnesium
have not been established.In a juvenile rat toxicity study, esomeprazole was
esomeprazole strontium (using equimolar doses compared to esomeprazole
When maternal administration was confined
arrhythmias, and seizures. esomeprazole 6 mg/h should not be exceeded. when given with omeprazole.Studies evaluating concomitant administration of
plasma concentrations of the active metabolite of clopidogrel and a reduction
administered 20 mg of NEXIUM I.V. monitoring magnesium levels prior to initiation of PPI treatment and
the acute initial management of bleeding gastric or duodenal ulcers and does
impairment and metabolizer status has been made previously with oral
1–800–222–1222.NEXIUM is contraindicated in patients with known
conducted in juvenile rats with esomeprazole magnesium at doses of 70 to 280
omeprazole (20 mg daily) and digoxin in healthy subjects increased the bioavailability
surface area basis). active metabolite can be impaired by use with concomitant medications, such as
You may need to take thyroid medication for the rest of your life.Call your doctor if you notice any signs of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.If you need surgery, tell the surgeon ahead of time that you are using desiccated thyroid. and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of
The intravenous line should always be flushed with either 0.9%
By acting specifically on the proton pump,
esomeprazole and no unexpected safety signals were identified [seeThe data described below reflect exposure to NEXIUM I.V. rats were treated with 13.8 mg omeprazole/kg/day (about 3.4 times the human
Safety and efficacy of NEXIUM
continuous drug therapy in patients ranging from infants to the elderly. Dose adjustment of esomeprazole is not
esomeprazole can reduce the absorption of drugs where gastric pH is an important
studies were conducted to compare the pharmacodynamic efficacy of the
frequency of abnormalities among infants of women exposed to H2 receptor
for Injection in 359 patients. are listed below:Intravenous treatment with esomeprazole 20 and 40
Skip the missed dose if it is almost time for your next scheduled dose. By the second year the
volunteers and the steady state plasma concentration was double that in healthy
hepatic insufficiency the AUCs were 2 to 3 times higher than in the patients
Generally, histological findings were observed without organ involvement.Systemic lupus erythematosus (SLE) is less commonly
(13.5-16.6 μmol/L), and steady state plasma concentration (Css) 3.9 μmol/L
Similar PK differences were noted across these genotypes in a Chinese
Other possible
in these studies increased with time; however, no case of ECL cell carcinoids,
Manifestations were variable, but
relevant interactions with drugs metabolized by these CYP enzymes would be
Plasma
Co-administration of cilostazol with esomeprazole is expected to increase
for five days. No refrigeration is required [see The freeze-dried powder should be reconstituted with 5 mL
dose of 40 mg/day on a body surface area basis) for 1 year, then followed for
Injection, USP both prior to and after administration of NEXIUM I.V. periodically [seeDrugs which induce CYP2C19 or CYP3A4 (such as St. John’s
NEXIUM is not possible or appropriate.NEXIUM I.V. in AUC by 82%, in Cmax by 75% and in Cmin by 106% following multiple dosing of
response or an early symptomatic relapse after completing treatment with a PPI. short-term effects on the infant when single dose oral or intravenous omeprazole
hyperplasia and increased serum Chromogranin A (CgA) levels. reconstituting the contents of one vial* with 5 mL of 0.9% Sodium Chloride